Gene Review:
Ctsk - cathepsin K
Mus musculus
Synonyms:
AI323530, Cat K, Cathepsin K, MMS10-Q, Ms10q, ...
Matsumoto,
Chabaud,
Saftig,
von Figura,
Rodan,
Wehmeyer,
Beertsen,
Misson,
Kogawa,
Hoeben,
Fujisawa,
Takayanagi,
Boyde,
Saftig,
Jones,
Huaux,
Moritz,
Tsujimoto,
Furuyama,
Reinheckel,
van Den Berg,
Lubberts,
Wong,
Wesolowski,
Bühling,
Everts,
Rydzewski,
Oppers,
van Den Bersselaar,
Cleutjens,
Peters,
Miossec,
Hunziker,
Richards,
Korper,
Joosten,
van den Brûle,
Katayama,
Wada,
Hisatake,
Nogi,
Heeneman,
Bryant,
Coenen-De Roo,
Bromme,
Jansen,
Oballa,
Schu,
Bass,
Rommerskirch,
Lison,
- Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Kiviranta, R., Morko, J., Alatalo, S.L., NicAmhlaoibh, R., Risteli, J., Laitala-Leinonen, T., Vuorio, E. Bone (2005)
- Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta. van den Brûle, S., Misson, P., Bühling, F., Lison, D., Huaux, F. Respir. Res. (2005)
- Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Saftig, P., Hunziker, E., Wehmeyer, O., Jones, S., Boyde, A., Rommerskirch, W., Moritz, J.D., Schu, P., von Figura, K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. Morko, J., Kiviranta, R., Joronen, K., Säämänen, A.M., Vuorio, E., Salminen-Mankonen, H. Arthritis Rheum. (2005)
- Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Gelb, B.D., Shi, G.P., Chapman, H.A., Desnick, R.J. Science (1996)
- Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL. Kawaida, R., Ohtsuka, T., Okutsu, J., Takahashi, T., Kadono, Y., Oda, H., Hikita, A., Nakamura, K., Tanaka, S., Furukawa, H. J. Exp. Med. (2003)
- Thyroid functions of mouse cathepsins B, K, and L. Friedrichs, B., Tepel, C., Reinheckel, T., Deussing, J., von Figura, K., Herzog, V., Peters, C., Saftig, P., Brix, K. J. Clin. Invest. (2003)
- IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. Lubberts, E., Joosten, L.A., Chabaud, M., van Den Bersselaar, L., Oppers, B., Coenen-De Roo, C.J., Richards, C.D., Miossec, P., van Den Berg, W.B. J. Clin. Invest. (2000)
- Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones. Xia, L., Kilb, J., Wex, H., Li, Z., Lipyansky, A., Breuil, V., Stein, L., Palmer, J.T., Dempster, D.W., Brömme, D. Biol. Chem. (1999)
- Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors. Rydzewski, R.M., Bryant, C., Oballa, R., Wesolowski, G., Rodan, S.B., Bass, K.E., Wong, D.H. Bioorg. Med. Chem. (2002)
- Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. Stroup, G.B., Lark, M.W., Veber, D.F., Bhattacharyya, A., Blake, S., Dare, L.C., Erhard, K.F., Hoffman, S.J., James, I.E., Marquis, R.W., Ru, Y., Vasko-Moser, J.A., Smith, B.R., Tomaszek, T., Gowen, M. J. Bone Miner. Res. (2001)
- Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3. Rantakokko, J., Kiviranta, R., Eerola, R., Aro, H.T., Vuorio, E. Matrix Biol. (1999)
- Study of the functional share of lysosomal cathepsins by the development of specific inhibitors. Katunuma, N., Matsui, A., Kakegawa, T., Murata, E., Asao, T., Ohba, Y. Adv. Enzyme Regul. (1999)
- CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Chung, D.H., Humphrey, M.B., Nakamura, M.C., Ginzinger, D.G., Seaman, W.E., Daws, M.R. J. Immunol. (2003)
- Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression. Li, Y.P., Chen, W. J. Bone Miner. Res. (1999)
- Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. Tepel, C., Brömme, D., Herzog, V., Brix, K. J. Cell. Sci. (2000)
- Calvarial Osteoclasts Express a Higher Level of Tartrate-Resistant Acid Phosphatase than Long Bone Osteoclasts and Activation Does not Depend on Cathepsin K or L Activity. Perez-Amodio, S., Jansen, D.C., Schoenmaker, T., Vogels, I.M., Reinheckel, T., Hayman, A.R., Cox, T.M., Saftig, P., Beertsen, W., Everts, V. Calcif. Tissue Int. (2006)
- Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. Wilson, S.R., Peters, C., Saftig, P., Brömme, D. J. Biol. Chem. (2009)
- Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S., Hisatake, K., Nogi, Y. J. Biol. Chem. (2004)
- Interferon-gamma down-regulates gene expression of cathepsin K in osteoclasts and inhibits osteoclast formation. Kamolmatyakul, S., Chen, W., Li, Y.P. J. Dent. Res. (2001)
- Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy. Yamaza, T., Tsuji, Y., Goto, T., Kido, M.A., Nishijima, K., Moroi, R., Akamine, A., Tanaka, T. Bone (2001)
- Regulation of collagenolytic protease secretion through c-Src in osteoclasts. Furuyama, N., Fujisawa, Y. Biochem. Biophys. Res. Commun. (2000)
- Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. Everts, V., Korper, W., Hoeben, K.A., Jansen, I.D., Bromme, D., Cleutjens, K.B., Heeneman, S., Peters, C., Reinheckel, T., Saftig, P., Beertsen, W. J. Bone Miner. Res. (2006)
- Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic. Lutgens, S., Kisters, N., Lutgens, E., van Haaften, R., Evelo, C., de Winther, M., Saftig, P., Daemen, M., Heeneman, S., Cleutjens, K. J. Pathol. (2006)
- Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development. Dodds, R.A., Connor, J.R., Drake, F., Feild, J., Gowen, M. J. Bone Miner. Res. (1998)