Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN7724517 N-[4-methoxy-3-(4- methylpiperazin-1...

Synonyms: AC1NSK1Z, PDSP1_001398, PDSP2_001382, GR125743, GR 125,743, ...

van den Broek, R.W. et al., Gupta, S. et al.

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High impact information on GR125743

However, the potency of both sumatriptan and GR125743 was positively correlated to the gestational age in the normotensive group, whereas this relationship was absent in the pre-eclamptic group [1].
In contrast, the potencies of sumatriptan and GR125743 were significantly higher in normotensive full-term pregnancies than in normotensive pre-term pregnancies in UCA [1].
In the human coronary artery and saphenous vein, sumatriptan-induced contractions (pEC(50): 6.24+/-0.14 and 6.19+/-0.12, respectively) were also potently antagonised by GR125743 (pA(2): 8.18+/-0.27 and 8.34+/-0.12, respectively) [2].
In the middle meningeal artery, GR125743 antagonised the contractions induced by both eletriptan (pEC(50): 7.34+/-0.13) and sumatriptan (pEC(50): 6.91+/-0.17) to a similar degree (pA(2): 8. 81+/-0.17 and 8.64+/-0.21, respectively) [2].

References

Functional reactivity of 5-HT receptors in human umbilical cord and maternal subcutaneous fat arteries after normotensive or pre-eclamptic pregnancy. Gupta, S., Hanff, L.M., Visser, W., Steegers, E.A., Saxena, P.R., Vulto, A.G., MaassenVanDenBrink, A. J. Hypertens. (2006) [Pubmed]
Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels. van den Broek, R.W., MaassenVanDenBrink, A., de Vries, R., Bogers, A.J., Stegmann, A.P., Avezaat, C.J., Saxena, P.R. Eur. J. Pharmacol. (2000) [Pubmed]

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