Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NT0QE 2-[4-[(5S,10S,13R,17R)- 3,7,12-trihydroxy...

Synonyms:

Hara, T.J. et al., Duerksen, D.R. et al., Bowmer, C.J. et al., Hirano, M. et al.

Hara, Zhang,

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Disease relevance of TAUROCHOLIC ACID

The newborn piglet is a valid model to study TPN-induced cholestasis, characterized by decreased bile acid secretion, impaired BADF and BAIF, and reduced bile flow stimulation after intravenous TCA [1].

High impact information on TAUROCHOLIC ACID

A mutual inhibition study between TCA and pravastatin revealed that they competitively interact with hBSEP [2].
It is concluded that the decreased uptake of BSP was not due to a non-specific disturbance of hepatocyte function in ARF because the hepatic handling of ouabain and TChA were unaltered [3].
We conclude that in salmonid fishes olfactory neurons responsive to AA and TCA are randomly distributed throughout the olfactory epithelium, and yet project to spatially segregated regions and thereby generated signals are encoded independently in the bulb [4].
EEGs to AA and TCA distributed in two segregated regions, lateroposterior and mid olfactory bulb [4].

References

Total parenteral nutrition impairs bile flow and alters bile composition in newborn piglet. Duerksen, D.R., Van Aerde, J.E., Chan, G., Thomson, A.B., Jewell, L.J., Clandinin, M.T. Dig. Dis. Sci. (1996) [Pubmed]
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. Hirano, M., Maeda, K., Hayashi, H., Kusuhara, H., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
Pharmacokinetics and biliary excretion of bromosulphophthalein, [3H]-ouabain and [3H]-taurocholic acid in rats with glycerol-induced acute renal failure. Bowmer, C.J., Yates, M.S. Br. J. Pharmacol. (1984) [Pubmed]
Spatial projections to the olfactory bulb of functionally distinct and randomly distributed primary neurons in salmonid fishes. Hara, T.J., Zhang, C. Neurosci. Res. (1996) [Pubmed]

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