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MeSH Review

Olfactory Bulb

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Disease relevance of Olfactory Bulb


Psychiatry related information on Olfactory Bulb


High impact information on Olfactory Bulb


Chemical compound and disease context of Olfactory Bulb


Biological context of Olfactory Bulb


Anatomical context of Olfactory Bulb

  • Although numerous BrdU-labeled cells were distributed throughout the cerebral wall, including the neocortex, these were identified as nonneuronal cells; evidence for newly generated neurons was limited to the hippocampus and olfactory bulb [20].
  • In the accessory olfactory system, the G(o)-containing neurons in the basal vomeronasal organ (VNO) project to the posterior accessory olfactory bulb (AOB), whereas more apically located VNO neurons contain G(i2) and project to the anterior AOB [21].
  • The posterodorsal part of the medial nucleus of the amygdala (MeAp) receives its major sensory input from the accessory olfactory bulb and projects massively to the medial preoptic nucleus and other sexually dimorphic hypothalamic nuclei thought to play key roles in mediating steroid-sensitive reproductive functions [22].
  • In situ hybridization studies reveal a resemblance of HAP1 and neuronal nitric oxide synthase (nNOS) mRNA localizations with dramatic enrichment of both in the pedunculopontine nuclei, the accessory olfactory bulb, and the supraoptic nucleus of the hypothalamus [23].
  • D1 and D2 were differentially enriched in striatal patch and matrix compartments, in selective layers of the olfactory bulb, and in either substantia nigra pars compacta or reticulata [24].

Associations of Olfactory Bulb with chemical compounds


Gene context of Olfactory Bulb


Analytical, diagnostic and therapeutic context of Olfactory Bulb


  1. CHARGE syndrome includes hypogonadotropic hypogonadism and abnormal olfactory bulb development. Pinto, G., Abadie, V., Mesnage, R., Blustajn, J., Cabrol, S., Amiel, J., Hertz-Pannier, L., Bertrand, A.M., Lyonnet, S., Rappaport, R., Netchine, I. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  2. Olfaction and Parkinson's syndromes: its role in differential diagnosis. Katzenschlager, R., Lees, A.J. Curr. Opin. Neurol. (2004) [Pubmed]
  3. Role of neuropeptide Y in the regulation of gonadotropin releasing hormone system in the forebrain of Clarias batrachus (Linn.): immunocytochemistry and high performance liquid chromatography-electrospray ionization-mass spectrometric analysis. Gaikwad, A., Biju, K.C., Muthal, P.L., Saha, S., Subhedar, N. Neuroscience (2005) [Pubmed]
  4. Aging of the rat olfactory bulb: growth and atrophy of constituent layers and changes in size and number of mitral cells. Hinds, J.W., McNelly, N.A. J. Comp. Neurol. (1977) [Pubmed]
  5. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Huisman, E., Uylings, H.B., Hoogland, P.V. Mov. Disord. (2004) [Pubmed]
  6. Loss of dopamine receptors in the olfactory bulb of patients with Alzheimer's disease. Loopuijt, L.D., Sebens, J.B. Brain Res. (1990) [Pubmed]
  7. Olfactory bulb involvement in Pick's disease. Yoshimura, N. Acta Neuropathol. (1988) [Pubmed]
  8. Bicuculline infusion into the accessory olfactory bulb facilitates the induction of maternal behavior in rats. Carretero, M.I., Segovia, S., Gomez, F., Del Cerro, M.C. Scandinavian journal of psychology. (2003) [Pubmed]
  9. Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Rodriguez, I., Feinstein, P., Mombaerts, P. Cell (1999) [Pubmed]
  10. A map of pheromone receptor activation in the mammalian brain. Belluscio, L., Koentges, G., Axel, R., Dulac, C. Cell (1999) [Pubmed]
  11. Formation of olfactory memories mediated by nitric oxide. Kendrick, K.M., Guevara-Guzman, R., Zorrilla, J., Hinton, M.R., Broad, K.D., Mimmack, M., Ohkura, S. Nature (1997) [Pubmed]
  12. Nitric oxide mediates network oscillations of olfactory interneurons in a terrestrial mollusc. Gelperin, A. Nature (1994) [Pubmed]
  13. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa-Meguro, R., Shigemoto, R., Mizuno, N., Nakanishi, S. Nature (1993) [Pubmed]
  14. Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2). Albuisson, J., Pêcheux, C., Carel, J.C., Lacombe, D., Leheup, B., Lapuzina, P., Bouchard, P., Legius, E., Matthijs, G., Wasniewska, M., Delpech, M., Young, J., Hardelin, J.P., Dodé, C. Hum. Mutat. (2005) [Pubmed]
  15. L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor. Trombley, P.Q., Westbrook, G.L. J. Neurosci. (1992) [Pubmed]
  16. Differential localization of G-proteins Gi and Go in the accessory olfactory bulb of the rat. Shinohara, H., Asano, T., Kato, K. J. Neurosci. (1992) [Pubmed]
  17. Localization of atrial natriuretic factor (ANF) binding sites in the central nervous system of the frog. Tong, Y., Netchitaïlo, P., Leboulenger, F., Vaudry, H., Pelletier, G. J. Comp. Neurol. (1989) [Pubmed]
  18. Sex difference and testosterone modulation of pheromone-induced NeuronalFos in the Ferret's main olfactory bulb and hypothalamus. Kelliher, K.R., Chang, Y.M., Wersinger, S.R., Baum, M.J. Biol. Reprod. (1998) [Pubmed]
  19. Integration of chemosensory and hormonal cues is essential for sexual behaviour in the male Syrian hamster: role of the medial amygdaloid nucleus. Wood, R.I., Coolen, L.M. Neuroscience (1997) [Pubmed]
  20. Cell proliferation without neurogenesis in adult primate neocortex. Kornack, D.R., Rakic, P. Science (2001) [Pubmed]
  21. G(o) protein-dependent survival of primary accessory olfactory neurons. Tanaka, M., Treloar, H., Kalb, R.G., Greer, C.A., Strittmatter, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway. Simerly, R.B., Young, B.J., Capozza, M.A., Swanson, L.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  23. Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Li, X.J., Sharp, A.H., Li, S.H., Dawson, T.M., Snyder, S.H., Ross, C.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Levey, A.I., Hersch, S.M., Rye, D.B., Sunahara, R.K., Niznik, H.B., Kitt, C.A., Price, D.L., Maggio, R., Brann, M.R., Ciliax, B.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  25. Male vole urine changes luteinizing hormone-releasing hormone and norepinephrine in female olfactory bulb. Dluzen, D.E., Ramirez, V.D., Carter, C.S., Getz, L.L. Science (1981) [Pubmed]
  26. Newly generated neurons in the amygdala and adjoining cortex of adult primates. Bernier, P.J., Bedard, A., Vinet, J., Levesque, M., Parent, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI. Xu, F., Kida, I., Hyder, F., Shulman, R.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  28. The cholinergic system in Alzheimer's disease. Kása, P., Rakonczay, Z., Gulya, K. Prog. Neurobiol. (1997) [Pubmed]
  29. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Matsumoto, S., Yamazaki, C., Masumoto, K.H., Nagano, M., Naito, M., Soga, T., Hiyama, H., Matsumoto, M., Takasaki, J., Kamohara, M., Matsuo, A., Ishii, H., Kobori, M., Katoh, M., Matsushime, H., Furuichi, K., Shigeyoshi, Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Polysialic acid facilitates migration of luteinizing hormone-releasing hormone neurons on vomeronasal axons. Yoshida, K., Rutishauser, U., Crandall, J.E., Schwarting, G.A. J. Neurosci. (1999) [Pubmed]
  31. The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse. Levi, G., Puche, A.C., Mantero, S., Barbieri, O., Trombino, S., Paleari, L., Egeo, A., Merlo, G.R. Mol. Cell. Neurosci. (2003) [Pubmed]
  32. Characterization of olfactory bulb glomeruli in schizophrenia. Rioux, L., Gelber, E.I., Parand, L., Kazi, H.A., Yeh, J., Wintering, R., Bilker, W., Arnold, S.E. Schizophr. Res. (2005) [Pubmed]
  33. Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1. Pichel, J.G., Fernández-Moreno, C., Vicario-Abejón, C., Testillano, P.S., Patterson, P.H., de Pablo, F. Mech. Dev. (2003) [Pubmed]
  34. Excitatory and inhibitory synaptic processing in the accessory olfactory system of the female rat. Wong, M., Chen, Y., Moss, R.L. Neuroscience (1993) [Pubmed]
  35. Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice. Jiménez, D., García, C., de Castro, F., Chédotal, A., Sotelo, C., de Carlos, J.A., Valverde, F., López-Mascaraque, L. J. Comp. Neurol. (2000) [Pubmed]
  36. Increase in the number of tyrosine hydroxylase-containing neurons in a primary culture system of the rat accessory olfactory bulb by co-culture with vomeronasal pockets. Muramoto, K., Osada, T., Kato-Negishi, M., Kuroda, Y., Ichikawa, M. Neuroscience (2003) [Pubmed]
  37. Localization and pharmacological characterization of pigeon diazepam-insensitive GABAA receptors. Acri, J.B., Wong, G., Lyon, T., Witkin, J.M., Basile, A.S. Neuroscience (1997) [Pubmed]
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