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Chemical Compound Review

Fexaramine     methyl(E)-3-[3- [cyclohexylcarbonyl-[[4-(4...

Synonyms: CHEMBL192966, CHEBI:419274, KB-69557, AC1NS0YI, C15649, ...
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High impact information on Fexaramine

  • The discovery of fexaramine will allow us to unravel the FXR genetic network from the BA network and selectively manipulate components of the cholesterol pathway that may be useful in treating cholesterol-related human diseases [1].

Gene context of Fexaramine

  • Highly diffracting cocrystals (1.78 A) of fexaramine bound to the ligand binding domain of FXR revealed the agonist sequestered in a 726 A(3) hydrophobic cavity and suggest a mechanistic basis for the initial step in the BA signaling pathway [1].


  1. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G., Noel, J.P., Nicolaou, K.C., Evans, R.M. Mol. Cell (2003) [Pubmed]
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