Gene Review:
Nr1h4 - nuclear receptor subfamily 1, group H,...
Mus musculus
Synonyms:
AI957360, Bar, Bile acid receptor, FXR, Farnesoid X-activated receptor, ...
- FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Wittenburg, H., Lyons, M.A., Li, R., Churchill, G.A., Carey, M.C., Paigen, B. Gastroenterology (2003)
- Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. Yamamoto, Y., Moore, R., Hess, H.A., Guo, G.L., Gonzalez, F.J., Korach, K.S., Maronpot, R.R., Negishi, M. J. Biol. Chem. (2006)
- Repression of farnesoid X receptor during the acute phase response. Kim, M.S., Shigenaga, J., Moser, A., Feingold, K., Grunfeld, C. J. Biol. Chem. (2003)
- A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. Shih, D.M., Kast-Woelbern, H.R., Wong, J., Xia, Y.R., Edwards, P.A., Lusis, A.J. J. Lipid Res. (2006)
- Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver. Zollner, G., Wagner, M., Fickert, P., Geier, A., Fuchsbichler, A., Silbert, D., Gumhold, J., Zatloukal, K., Kaser, A., Tilg, H., Denk, H., Trauner, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-{alpha}/beta in the adaptive response to bile acids. Zollner, G., Wagner, M., Moustafa, T., Fickert, P., Silbert, D., Gumhold, J., Fuchsbichler, A., Halilbasic, E., Denk, H., Marschall, H.U., Trauner, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Sinal, C.J., Tohkin, M., Miyata, M., Ward, J.M., Lambert, G., Gonzalez, F.J. Cell (2000)
- Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Moschetta, A., Bookout, A.L., Mangelsdorf, D.J. Nat. Med. (2004)
- Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Zhang, Y., Castellani, L.W., Sinal, C.J., Gonzalez, F.J., Edwards, P.A. Genes Dev. (2004)
- Farnesoid X receptor is essential for normal glucose homeostasis. Ma, K., Saha, P.K., Chan, L., Moore, D.D. J. Clin. Invest. (2006)
- Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. Guo, G.L., Lambert, G., Negishi, M., Ward, J.M., Brewer, H.B., Kliewer, S.A., Gonzalez, F.J., Sinal, C.J. J. Biol. Chem. (2003)
- Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Rizzo, G., Renga, B., Mencarelli, A., Pellicciari, R., Fiorucci, S. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2005)
- Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. Kitada, H., Miyata, M., Nakamura, T., Tozawa, A., Honma, W., Shimada, M., Nagata, K., Sinal, C.J., Guo, G.L., Gonzalez, F.J., Yamazoe, Y. J. Biol. Chem. (2003)
- Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. Miyata, M., Tozawa, A., Otsuka, H., Nakamura, T., Nagata, K., Gonzalez, F.J., Yamazoe, Y. J. Pharmacol. Exp. Ther. (2005)
- Amplification and overexpression of oncogene Mdm2 and orphan receptor gene Nr1h4 in immortal PRKDC knockout cells. Ai, R., Sandoval, A., Chen, D.J., Burma, S., Labhart, P. Mol. Biol. Rep. (2004)
- Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy. Sweeney, T.R., Moser, A.H., Shigenaga, J.K., Grunfeld, C., Feingold, K.R. Am. J. Physiol. Endocrinol. Metab. (2006)
- Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. Qin, P., Borges-Marcucci, L.A., Evans, M.J., Harnish, D.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Inagaki, T., Moschetta, A., Lee, Y.K., Peng, L., Zhao, G., Downes, M., Yu, R.T., Shelton, J.M., Richardson, J.A., Repa, J.J., Mangelsdorf, D.J., Kliewer, S.A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. Kast, H.R., Goodwin, B., Tarr, P.T., Jones, S.A., Anisfeld, A.M., Stoltz, C.M., Tontonoz, P., Kliewer, S., Willson, T.M., Edwards, P.A. J. Biol. Chem. (2002)
- Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. Marschall, H.U., Wagner, M., Bodin, K., Zollner, G., Fickert, P., Gumhold, J., Silbert, D., Fuchsbichler, A., Sjövall, J., Trauner, M. J. Lipid Res. (2006)
- Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. Zhang, Y., Kast-Woelbern, H.R., Edwards, P.A. J. Biol. Chem. (2003)
- Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. Mak, P.A., Kast-Woelbern, H.R., Anisfeld, A.M., Edwards, P.A. J. Lipid Res. (2002)
- Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor. Campana, G., Pasini, P., Roda, A., Spampinato, S. Biochem. Pharmacol. (2005)
- Regulation of the mouse organic solute transporter {alpha}-beta, Ost{alpha}-Ostbeta, by bile acids. Frankenberg, T., Rao, A., Chen, F., Haywood, J., Shneider, B.L., Dawson, P.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- LXR Alpha Transactivates Mouse Organic Solute Transporter Alpha and Beta via IR-1 Elements Shared with FXR. Okuwaki, M., Takada, T., Iwayanagi, Y., Koh, S., Kariya, Y., Fujii, H., Suzuki, H. Pharm. Res. (2007)
- Pregnane X receptor is a target of farnesoid X receptor. Jung, D., Mangelsdorf, D.J., Meyer, U.A. J. Biol. Chem. (2006)
- Regulation of drug transporters by the farnesoid X receptor in mice. Maeda, T., Miyata, M., Yotsumoto, T., Kobayashi, D., Nozawa, T., Toyama, K., Gonzalez, F.J., Yamazoe, Y., Tamai, I. Mol. Pharm. (2004)
- FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. Lee, H., Zhang, Y., Lee, F.Y., Nelson, S.F., Gonzalez, F.J., Edwards, P.A. J. Lipid Res. (2006)
- Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. Liu, Y., Binz, J., Numerick, M.J., Dennis, S., Luo, G., Desai, B., MacKenzie, K.I., Mansfield, T.A., Kliewer, S.A., Goodwin, B., Jones, S.A. J. Clin. Invest. (2003)