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Chemical Compound Review

sulfasalazine     (3E)-6-oxo-3-[[4-(pyridin-2...

Synonyms: Sulphasalazine, Azulfidine EN, CHEMBL421, Sas-500, BSPBio_000479, ...
 
 
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Disease relevance of Asulfidine

  • Our findings suggest that UDCA rather than sulfasalazine could serve as an effective suppressing agent in colitis-related colon cancer development in mice [1].
  • Patients treated with EI using intraarticular corticosteroids followed by sulfasalazine therapy if resistant demonstrated reduced synovitis 12 months after treatment compared with those initially treated with more conservative therapy [2].
 

Gene context of Asulfidine

  • Nuclear factor-kappaB (NF-kappaB) signaling activity is associated with AXL expression and may play an important role in the enhancement of invasiveness and doxorubicin resistance, as shown by using the NF-kappaB inhibitor, sulfasalazine, and IkappaB dominant-negative transfectants [3].

References

  1. Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. Kohno, H., Suzuki, R., Yasui, Y., Miyamoto, S., Wakabayashi, K., Tanaka, T. Clin. Cancer Res. (2007) [Pubmed]
  2. A randomized controlled trial of early intervention with intraarticular corticosteroids followed by sulfasalazine versus conservative treatment in early oligoarthritis. Marzo-Ortega, H., Green, M.J., Keenan, A.M., Wakefield, R.J., Proudman, S., Emery, P. Arthritis Rheum. (2007) [Pubmed]
  3. Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. Lay, J.D., Hong, C.C., Huang, J.S., Yang, Y.Y., Pao, C.Y., Liu, C.H., Lai, Y.P., Lai, G.M., Cheng, A.L., Su, I.J., Chuang, S.E. Cancer Res. (2007) [Pubmed]
 
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