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Chemical Compound Review:

sulfasalazine (3E)-6-oxo-3-[[4-(pyridin-2...

Synonyms: Sulphasalazine, Azulfidine EN, CHEMBL421, Sas-500, BSPBio_000479, ...

Lay, J.D. et al., Marzo-Ortega, H. et al., Kohno, H. et al.

Shingo Miyamoto, Rikako Suzuki, Yumiko Yasui, Takuji Tanaka, Keiji Wakabayashi, Hiroyuki Kohno,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Asulfidine

Our findings suggest that UDCA rather than sulfasalazine could serve as an effective suppressing agent in colitis-related colon cancer development in mice [1].
Patients treated with EI using intraarticular corticosteroids followed by sulfasalazine therapy if resistant demonstrated reduced synovitis 12 months after treatment compared with those initially treated with more conservative therapy [2].

Gene context of Asulfidine

Nuclear factor-kappaB (NF-kappaB) signaling activity is associated with AXL expression and may play an important role in the enhancement of invasiveness and doxorubicin resistance, as shown by using the NF-kappaB inhibitor, sulfasalazine, and IkappaB dominant-negative transfectants [3].

References

Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. Kohno, H., Suzuki, R., Yasui, Y., Miyamoto, S., Wakabayashi, K., Tanaka, T. Clin. Cancer Res. (2007) [Pubmed]
A randomized controlled trial of early intervention with intraarticular corticosteroids followed by sulfasalazine versus conservative treatment in early oligoarthritis. Marzo-Ortega, H., Green, M.J., Keenan, A.M., Wakefield, R.J., Proudman, S., Emery, P. Arthritis Rheum. (2007) [Pubmed]
Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. Lay, J.D., Hong, C.C., Huang, J.S., Yang, Y.Y., Pao, C.Y., Liu, C.H., Lai, Y.P., Lai, G.M., Cheng, A.L., Su, I.J., Chuang, S.E. Cancer Res. (2007) [Pubmed]

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