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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Synovitis

  • Chronic synovitis in gout simulating rheumatoid arthritis. Demonstration of bilateral popliteal cysts and wrist synovial corrugation [1].
  • However, unlike mice with null mutations in any of the components in the gp130 signaling pathway, gp130(DeltaSTAT) mice also displayed gastrointestinal ulceration and a severe joint disease with features of chronic synovitis, cartilaginous metaplasia, and degradation of the articular cartilage [2].
  • These results suggest that HTLV-I can infect synovial cells, resulting their active proliferation and may be involved in the pathogenesis of proliferative synovitis similar to that found in rheumatoid arthritis [3].
  • We conclude that there is a strong association between HLA B27 and chronic synovitis in Indian patients with severe haemophilia and screening in this population could allow treatment and prevention of the complication [4].
  • Increased levels of ICAM-1 transcripts were observed in the biopsy specimens obtained from AOSD patients with Still's rash or synovitis compared with healthy skin and patients with osteoarthritis [5].

High impact information on Synovitis

  • Thirty-six patients with primary osteoporosis were treated for up to six years with sodium fluoride, calcium supplements, and, in 24 patients, vitamin D. Major adverse reactions (synovitis, painful plantar fascial syndrome, recurrent vomiting, or anemia) occurred in 15 patients (42%) [6].
  • This mechanism is dependent on the signaling pathway intermediary myeloid differentiation factor 88 (MyD88), such that neither IL-1R nor MyD88-deficient mice developed visually detectable synovitis after transfer of arthritogenic sera [7].
  • GC+ synovitis had the highest levels of APRIL, produced exclusively by CD83+ DCs [8].
  • In contrast, inhibition of APRIL and BLyS in aggregate and diffuse synovitis left Ig levels unaffected and enhanced IFN-gamma production [8].
  • The study has important implications for understanding the role of OPN in rheumatoid synovitis and other inflammatory conditions [9].

Chemical compound and disease context of Synovitis

  • These results indicate that, in chronic IgG-induced immune synovitis, anti-proteoglycan antibodies elicited are heterogeneous with regard to specificity, but a relatively large proportion predominantly recognized a portion of the proteoglycan molecule containing core protein and associated keratan sulfate [10].
  • c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide [11].
  • The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis [12].
  • The role of osmic acid in the treatment of immune synovitis [13].
  • Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis [14].

Biological context of Synovitis


Anatomical context of Synovitis


Gene context of Synovitis

  • In contrast, extra-articular spreading of RA with nodule formation was typically associated with granulomatous synovitis [25].
  • These data suggest that VEGF plays a crucial role during an early stage of arthritis development, affecting both neovascularization and the progression of experimentally induced synovitis [26].
  • In follicular synovitis, IFN-gamma was the dominant cytokine, IL-4 was virtually undetectable, and IL-10 was abundant [25].
  • CONCLUSION: IL-18 augments monocyte activation induced by contact with activated T cells in RA synovitis, which is dependent on activation of the NF-kappaB and PI 3-kinase pathways [27].
  • The levels of ICAM-1 and VCAM-1 in the sublining layers correlated with the extent of macroscopic synovitis (P < 0.0005 and P < 0.005, respectively) [28].

Analytical, diagnostic and therapeutic context of Synovitis


  1. Chronic synovitis in gout simulating rheumatoid arthritis. Demonstration of bilateral popliteal cysts and wrist synovial corrugation. Trentham, E.D., Masi, A.T. JAMA (1976) [Pubmed]
  2. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. Ernst, M., Inglese, M., Waring, P., Campbell, I.K., Bao, S., Clay, F.J., Alexander, W.S., Wicks, I.P., Tarlinton, D.M., Novak, U., Heath, J.K., Dunn, A.R. J. Exp. Med. (2001) [Pubmed]
  3. Infection of human synovial cells by human T cell lymphotropic virus type I. Proliferation and granulocyte/macrophage colony-stimulating factor production by synovial cells. Sakai, M., Eguchi, K., Terada, K., Nakashima, M., Yamashita, I., Ida, H., Kawabe, Y., Aoyagi, T., Takino, H., Nakamura, T. J. Clin. Invest. (1993) [Pubmed]
  4. Chronic synovitis and HLA B27 in patients with severe haemophilia. Ghosh, K., Shankarkumar, U., Shetty, S., Mohanty, D. Lancet (2003) [Pubmed]
  5. Association of intercellular adhesion molecule-1 with clinical manifestations and interleukin-18 in patients with active, untreated adult-onset Still's disease. Chen, D.Y., Lan, J.L., Lin, F.J., Hsieh, T.Y. Arthritis Rheum. (2005) [Pubmed]
  6. Treatment of primary osteoporosis with fluoride and calcium. Clinical tolerance and fracture occurrence. Riggs, B.L., Hodgson, S.F., Hoffman, D.L., Kelly, P.J., Johnson, K.A., Taves, D. JAMA (1980) [Pubmed]
  7. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling. Choe, J.Y., Crain, B., Wu, S.R., Corr, M. J. Exp. Med. (2003) [Pubmed]
  8. BLyS and APRIL in rheumatoid arthritis. Seyler, T.M., Park, Y.W., Takemura, S., Bram, R.J., Kurtin, P.J., Goronzy, J.J., Weyand, C.M. J. Clin. Invest. (2005) [Pubmed]
  9. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. Xu, G., Nie, H., Li, N., Zheng, W., Zhang, D., Feng, G., Ni, L., Xu, R., Hong, J., Zhang, J.Z. J. Clin. Invest. (2005) [Pubmed]
  10. Epitopes of proteoglycans eliciting an anti-proteoglycan response in chronic immune synovitis. Yoo, J.U., Kresina, T.F., Malemud, C.J., Goldberg, V.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. Wen, F.Q., Jabbar, A.A., Chen, Y.X., Kazarian, T., Patel, D.A., Valentino, L.A. Blood (2002) [Pubmed]
  12. The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis. Terkeltaub, R., Baird, S., Sears, P., Santiago, R., Boisvert, W. Arthritis Rheum. (1998) [Pubmed]
  13. The role of osmic acid in the treatment of immune synovitis. Goldberg, V.M., Rashbaum, R., Zika, J. Arthritis Rheum. (1976) [Pubmed]
  14. Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. Tramontini, N., Huber, C., Liu-Bryan, R., Terkeltaub, R.A., Kilgore, K.S. Arthritis Rheum. (2004) [Pubmed]
  15. A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease. Bridges, A.J., Conley, C., Wang, G., Burns, D.E., Vasey, F.B. Ann. Intern. Med. (1993) [Pubmed]
  16. Drug treatment of rheumatic diseases in the 1990s. Achievements and future developments. Choy, E.H., Scott, D.L. Drugs (1997) [Pubmed]
  17. Tyrosine kinase signal transduction in rheumatoid synovitis. Williams, W.V., VonFeldt, J.M., Ramanujam, T., Weiner, D.B. Semin. Arthritis Rheum. (1992) [Pubmed]
  18. Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59. Mizuno, M., Nishikawa, K., Morgan, B.P., Matsuo, S. Clin. Exp. Immunol. (2000) [Pubmed]
  19. Cellular immunity in the joints of patients with rheumatoid arthritis and other forms of chronic synovitis. Firestein, G.S., Tsai, V., Zvaifler, N.J. Rheum. Dis. Clin. North Am. (1987) [Pubmed]
  20. Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions. Rubin, K., Tingström, A., Hansson, G.K., Larsson, E., Rönnstrand, L., Klareskog, L., Claesson-Welsh, L., Heldin, C.H., Fellström, B., Terracio, L. Lancet (1988) [Pubmed]
  21. Increased levels of proteoglycan fragments in knee joint fluid after injury. Lohmander, L.S., Dahlberg, L., Ryd, L., Heinegård, D. Arthritis Rheum. (1989) [Pubmed]
  22. Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Hale, L.P., Martin, M.E., McCollum, D.E., Nunley, J.A., Springer, T.A., Singer, K.H., Haynes, B.F. Arthritis Rheum. (1989) [Pubmed]
  23. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Panayi, G.S., Lanchbury, J.S., Kingsley, G.H. Arthritis Rheum. (1992) [Pubmed]
  24. Inhibition by cyclosporin A of streptococcal cell wall-induced arthritis and hepatic granulomas in rats. Yocum, D.E., Allen, J.B., Wahl, S.M., Calandra, G.B., Wilder, R.L. Arthritis Rheum. (1986) [Pubmed]
  25. Tissue cytokine patterns distinguish variants of rheumatoid synovitis. Klimiuk, P.A., Goronzy, J.J., Björ nsson, J., Beckenbaugh, R.D., Weyand, C.M. Am. J. Pathol. (1997) [Pubmed]
  26. Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis. Lu, J., Kasama, T., Kobayashi, K., Yoda, Y., Shiozawa, F., Hanyuda, M., Negishi, M., Ide, H., Adachi, M. J. Immunol. (2000) [Pubmed]
  27. Interleukin-18 enhances monocyte tumor necrosis factor alpha and interleukin-1beta production induced by direct contact with T lymphocytes: implications in rheumatoid arthritis. Dai, S.M., Matsuno, H., Nakamura, H., Nishioka, K., Yudoh, K. Arthritis Rheum. (2004) [Pubmed]
  28. Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. Barrera, P., Blom, A., van Lent, P.L., van Bloois, L., Beijnen, J.H., van Rooijen, N., de Waal Malefijt, M.C., van de Putte, L.B., Storm, G., van den Berg, W.B. Arthritis Rheum. (2000) [Pubmed]
  29. Stimulation of rabbit synoviocyte prostaglandin E2 synthesis by lipopolysaccharides and their subunit structures. Rothenberg, R.J., England, D., Qureshi, N., Takayama, K. Arthritis Rheum. (1988) [Pubmed]
  30. Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis. Szkudlarek, M., Court-Payen, M., Jacobsen, S., Klarlund, M., Thomsen, H.S., Østergaard, M. Arthritis Rheum. (2003) [Pubmed]
  31. Intra-articular primatised anti-CD4: efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology. Veale, D.J., Reece, R.J., Parsons, W., Radjenovic, A., O'Connor, P.J., Orgles, C.S., Berry, E., Ridgway, J.P., Mason, U., Boylston, A.W., Gibbon, W., Emery, P. Ann. Rheum. Dis. (1999) [Pubmed]
  32. Effect of iron complexes on adjuvant arthritis in rats. Dabbagh, A.J., Blake, D.R., Morris, C.J. Ann. Rheum. Dis. (1992) [Pubmed]
  33. Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Tomita, T., Takano, H., Tomita, N., Morishita, R., Kaneko, M., Shi, K., Takahi, K., Nakase, T., Kaneda, Y., Yoshikawa, H., Ochi, T. Rheumatology (Oxford, England) (2000) [Pubmed]
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