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Chemical Compound Review:

Celupan

Synonyms: Vivitrex, Vivitrol, MorViva, Depade, Naltrexona, ...

Krishnan-Sarin, S. et al., Weerts, E.M. et al.

John H. Krystal, Brian Pittman, Stephanie S. O'Malley, Suchitra Krishnan-Sarin, Julia Shi, Elise M. Weerts, Yu Kyeong Kim, Gary S. Wand, Robert F. Dannals, Jae Sung Lee, J. James Frost, Mary E. McCaul,

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Psychiatry related information on Celupan

These results suggest that family history of alcoholism might be a significant clinical predictor of response to naltrexone and that FH+ men are more likely to benefit from naltrexone therapy for alcohol drinking [1].
The lower percent inhibition of delta-OR and greater variability in delta-OR blockade by naltrexone across subjects may contribute to individual differences in treatment outcomes to naltrexone [2].

References

Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking. Krishnan-Sarin, S., Krystal, J.H., Shi, J., Pittman, B., O'Malley, S.S. Biol. Psychiatry (2007) [Pubmed]
Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Weerts, E.M., Kim, Y.K., Wand, G.S., Dannals, R.F., Lee, J.S., Frost, J.J., McCaul, M.E. Neuropsychopharmacology (2008) [Pubmed]

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