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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Individuality


Psychiatry related information on Individuality


High impact information on Individuality

  • Thus, genes coding for the GABAA receptor or associated proteins may be critical determinants of individual differences in ethanol sensitivity [11].
  • Our psychobiological threshold model explains the effects of individual differences in dopamine transmission on behavior, and their relation to personality traits is discussed [12].
  • Converging lines of evidence indicate that adolescence may be a sensitive period for steroid-dependent brain organization and that variation in the timing of interactions between the hormones of puberty and the adolescent brain leads to individual differences in adult behavior and risk of sex-biased psychopathologies [13].
  • These results provide the basis for future studies to determine the role of sulfation of peptides in humans and whether individual variations in tyrosylsulfotransferase activities correlate with individual differences in the degree of sulfate conjugation of peptides [14].
  • This study suggests that individual differences in susceptibility to diarrhea after milk ingestion by lactase-deficient subjects may be due to differences in the quantity of lactose not absorbed and/or differences in the rate of bacterial metabolism of lactose in the colon [15].

Chemical compound and disease context of Individuality


Biological context of Individuality


Anatomical context of Individuality

  • In addition, individual differences in spatial learning capacity among the aged rats correlated with levels of SYN staining selectively in three regions: outer and middle portions of the dentate gyrus molecular layer and CA3-LM [25].
  • These observations suggest that inherited variations in TS PST activity and thermal stability in an easily obtained tissue, the platelet, might be used to predict individual differences of those properties of the enzyme in the human small intestine, an organ that plays an important role in drug metabolism [26].
  • These results support the interpretation that LOW and HIGH feeders exhibit differences in presynaptic nucleus accumbens dopamine function that account for the expression of individual differences in sugar consumption and response to amphetamine treatments [27].
  • These data suggest that the mode of maternal use of cocaine and individual differences in placental handling of the drug may protect some fetuses, and highlight the need to address interpatient variability [28].
  • There was a large individual difference in the microsomal glucuronidation of cis-HO-TAM, which correlated well with glucuronidation of 4-hydroxybiphenyl by human liver microsomes [29].

Gene context of Individuality


Analytical, diagnostic and therapeutic context of Individuality


  1. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. Inoue, I., Nakajima, T., Williams, C.S., Quackenbush, J., Puryear, R., Powers, M., Cheng, T., Ludwig, E.H., Sharma, A.M., Hata, A., Jeunemaitre, X., Lalouel, J.M. J. Clin. Invest. (1997) [Pubmed]
  2. Intermittent thiamine deficiency in the rhesus monkey. I. Progression of neurological signs and neuroanatomical lesions. Witt, E.D., Goldman-Rakic, P.S. Ann. Neurol. (1983) [Pubmed]
  3. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. Aksoy, S., Szumlanski, C.L., Weinshilboum, R.M. J. Biol. Chem. (1994) [Pubmed]
  4. Polymorphisms in the 5' regulatory region of the tissue factor gene and the risk of myocardial infarction and venous thromboembolism: the ECTIM and PATHROS studies. Etude Cas-Témoins de l'Infarctus du Myocarde. Paris Thrombosis case-control Study. Arnaud, E., Barbalat, V., Nicaud, V., Cambien, F., Evans, A., Morrison, C., Arveiler, D., Luc, G., Ruidavets, J.B., Emmerich, J., Fiessinger, J.N., Aiach, M. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  5. Attachment representation and cortisol response to the adult attachment interview in idiopathic spasmodic torticollis. Scheidt, C.E., Waller, E., Malchow, H., Ehlert, U., Becker-Stoll, F., Schulte-Mönting, J., Lücking, C.H. Psychotherapy and psychosomatics. (2000) [Pubmed]
  6. Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules. Kabbaj, M., Devine, D.P., Savage, V.R., Akil, H. J. Neurosci. (2000) [Pubmed]
  7. Heritability of cortisol levels: review and simultaneous analysis of twin studies. Bartels, M., Van den Berg, M., Sluyter, F., Boomsma, D.I., de Geus, E.J. Psychoneuroendocrinology (2003) [Pubmed]
  8. Reinforcing effects of caffeine in humans. Griffiths, R.R., Woodson, P.P. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  9. Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Gerra, G., Zaimovic, A., Mascetti, G.G., Gardini, S., Zambelli, U., Timpano, M., Raggi, M.A., Brambilla, F. Psychoneuroendocrinology (2001) [Pubmed]
  10. Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse. Schenk, S., Lacelle, G., Gorman, K., Amit, Z. Neurosci. Lett. (1987) [Pubmed]
  11. Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. Wafford, K.A., Burnett, D.M., Dunwiddie, T.V., Harris, R.A. Science (1990) [Pubmed]
  12. Neurobiology of the structure of personality: dopamine, facilitation of incentive motivation, and extraversion. Depue, R.A., Collins, P.F. The Behavioral and brain sciences. (1999) [Pubmed]
  13. Pubertal hormones organize the adolescent brain and behavior. Sisk, C.L., Zehr, J.L. Frontiers in neuroendocrinology. (2005) [Pubmed]
  14. Human liver tyrosylsulfotransferase. Young, W.F. Gastroenterology (1990) [Pubmed]
  15. Quantitative measurement of lactose absorption. Bond, J.H., Levitt, M.D. Gastroenterology (1976) [Pubmed]
  16. A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity. Devor, E.J., Cloninger, C.R., Hoffman, P.L., Tabakoff, B. Am. J. Hum. Genet. (1991) [Pubmed]
  17. Recent progress in psychiatric genetics-some hope but no hype. Stoltenberg, S.F., Burmeister, M. Hum. Mol. Genet. (2000) [Pubmed]
  18. Individual differences in cognitive aging: implication of pregnenolone sulfate. Mayo, W., George, O., Darbra, S., Bouyer, J.J., Vallée, M., Darnaudéry, M., Pallarès, M., Lemaire-Mayo, V., Le Moal, M., Piazza, P.V., Abrous, N. Prog. Neurobiol. (2003) [Pubmed]
  19. Pharmacokinetics of fluorouracil in humans. MacMillan, W.E., Wolberg, W.H., Welling, P.G. Cancer Res. (1978) [Pubmed]
  20. Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans. Amiel, S.A., Simonson, D.C., Tamborlane, W.V., DeFronzo, R.A., Sherwin, R.S. Diabetes (1987) [Pubmed]
  21. The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Uhl, G.R., Sora, I., Wang, Z. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. The association between heel ultrasound and hormone replacement therapy is modulated by a two-locus vitamin D and estrogen receptor genotype. Giguère, Y., Dodin, S., Blanchet, C., Morgan, K., Rousseau, F. J. Bone Miner. Res. (2000) [Pubmed]
  23. Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin. Kawasaki, T., Ozeki, Y., Igawa, T., Kambayashi, J. Stroke (2000) [Pubmed]
  24. Replication timing of human telomeric DNA and other repetitive sequences analyzed by fluorescence in situ hybridization and flow cytometry. Hultdin, M., Grönlund, E., Norrback, K.F., Just, T., Taneja, K., Roos, G. Exp. Cell Res. (2001) [Pubmed]
  25. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. Smith, T.D., Adams, M.M., Gallagher, M., Morrison, J.H., Rapp, P.R. J. Neurosci. (2000) [Pubmed]
  26. Sulfation pharmacogenetics: correlation of human platelet and small intestinal phenol sulfotransferase. Sundaram, R.S., Van Loon, J.A., Tucker, R., Weinshilboum, R.M. Clin. Pharmacol. Ther. (1989) [Pubmed]
  27. Mesolimbic dopaminergic mechanisms underlying individual differences in sugar consumption and amphetamine hyperlocomotion in Wistar rats. Sills, T.L., Onalaja, A.O., Crawley, J.N. Eur. J. Neurosci. (1998) [Pubmed]
  28. Maternal cocaine use without evidence of fetal exposure. Potter, S., Klein, J., Valiante, G., Stack, D.M., Papageorgiou, A., Stott, W., Lewis, D., Koren, G., Zelazo, P.R. J. Pediatr. (1994) [Pubmed]
  29. Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases. Nishiyama, T., Ogura, K., Nakano, H., Ohnuma, T., Kaku, T., Hiratsuka, A., Muro, K., Watabe, T. Biochem. Pharmacol. (2002) [Pubmed]
  30. Interindividual difference in expression of human Ah receptor and related P450 genes. Hayashi, S., Watanabe, J., Nakachi, K., Eguchi, H., Gotoh, O., Kawajiri, K. Carcinogenesis (1994) [Pubmed]
  31. Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility. Kawajiri, K., Watanabe, J., Eguchi, H., Hayashi, S. Pharmacogenetics (1995) [Pubmed]
  32. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes. Xu, Z.H., Freimuth, R.R., Eckloff, B., Wieben, E., Weinshilboum, R.M. Pharmacogenetics (2002) [Pubmed]
  33. Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations. Raftogianis, R.B., Wood, T.C., Weinshilboum, R.M. Biochem. Pharmacol. (1999) [Pubmed]
  34. High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP). Massa, O., Meschi, F., Cuesta-Munoz, A., Caumo, A., Cerutti, F., Toni, S., Cherubini, V., Guazzarotti, L., Sulli, N., Matschinsky, F.M., Lorini, R., Iafusco, D., Barbetti, F. Diabetologia (2001) [Pubmed]
  35. Relaxation training for NIDDM. Predicting who may benefit. Lane, J.D., McCaskill, C.C., Ross, S.L., Feinglos, M.N., Surwit, R.S. Diabetes Care (1993) [Pubmed]
  36. Self-administration of intravenous amphetamine is predicted by individual differences in sucrose feeding in rats. DeSousa, N.J., Bush, D.E., Vaccarino, F.J. Psychopharmacology (Berl.) (2000) [Pubmed]
  37. Effects of acute ethanol on plasma and brain catecholamine levels in stressed and unstressed rats: evidence for an ethanol-stress interaction. DeTurck, K.H., Vogel, W.H. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  38. Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6. Ohnuma, T., Shibata, N., Matsubara, Y., Arai, H. British journal of clinical pharmacology. (2003) [Pubmed]
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