Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NUHOM (2R)-2-nitrobutane

Synonyms: InChI=1/C4H9NO2/c1-3-4(2)5(6)7/h4H,3H2,1-2H

Fiala, E.S. et al.

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Disease relevance of Butane, 2-nitro-

In a carcinogenicity assay using male F344 rats, the secondary nitroalkanes, 2-nitrobutane and 3-nitropentane, produced a highly significant incidence of hepatocarcinoma with metastases to the lungs, whereas the primary nitroalkane, 1-nitrobutane, was not carcinogenic [1].

References

Secondary nitroalkanes: induction of DNA repair in rat hepatocytes, activation by aryl sulfotransferase and hepatocarcinogenicity of 2-nitrobutane and 3-nitropentane in male F344 rats. Fiala, E.S., Sodum, R.S., Hussain, N.S., Rivenson, A., Dolan, L. Toxicology (1995) [Pubmed]

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