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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

90689-42-2     (NZ)-3,5-diamino-6-chloro-N- [[2-[(2,4...

Synonyms:
 
 
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Disease relevance of 90689-42-2

  • The amiloride derivative 2,4 dichlorobenzamil (DCB) inhibits the sodium-calcium exchanger (NCX) and was both antiproliferative and cytotoxic to glioma cells at low doses (20 microM) [1].
 

High impact information on 90689-42-2

  • 6. The presence of 2',4'-dichlorobenzamil amiloride (40 microM) significantly and similarly delayed and reduced the amplitude of transient recovery of tension in both normal and diabetic papillary muscles [2].
  • During the stable phase of the PTX-induced current, challenge with NiCl2 (5 mM) or 2,4-dichlorobenzamil (DCB, 25 microM), a non-selective cation channel blocker, partially reversed the current [3].
  • Preincubation with 2,4-dichlorobenzamil (10(-5) mol/L), inhibitor of the Na(+)-Ca(2+) exchanger, or KB-R7943 (10(-5) mol/L), selective inhibitor of the reverse mode of the Na(+)-Ca(2+) exchanger, abolished the increases in Phe contraction and (45)Ca(2+) influx at increasing [Na(+)](e) obtained by the addition of 1 to 6 mmol/L NaCl [4].

References

  1. Amiloride kills malignant glioma cells independent of its inhibition of the sodium-hydrogen exchanger. Hegde, M., Roscoe, J., Cala, P., Gorin, F. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  2. Decreased sensitivity of contraction to changes of intracellular pH in papillary muscle from diabetic rat hearts. Lagadic-Gossmann, D., Feuvray, D. J. Physiol. (Lond.) (1990) [Pubmed]
  3. Characterization of a palytoxin-induced non-selective cation channel in mouse megakaryocytes. Ichida, K., Ikeda, M., Goto, K., Ito, K. Jpn. J. Pharmacol. (1999) [Pubmed]
  4. Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt. Barron, L.A., Green, G.M., Khalil, R.A. Hypertension (2002) [Pubmed]
 
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