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MeSH Review

Glioma

 
 
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Disease relevance of Glioma

 

Psychiatry related information on Glioma

 

High impact information on Glioma

 

Chemical compound and disease context of Glioma

 

Biological context of Glioma

 

Anatomical context of Glioma

 

Gene context of Glioma

  • We demonstrate that expression of a constitutively active, mutant form of EGFR in cells in the glial lineage can induce lesions with many similarities to human gliomas [32].
  • None of the human malignant glioma cell lines was susceptible to TNF alpha-induced cytotoxicity [33].
  • In order to achieve specific targeting of the IL13R in gliomas, we have mutagenized human (h) IL13 [34].
  • Introduction of wild-type PTEN into glioma cells containing endogenous mutant alleles caused growth suppression, but was without effect in cells containing endogenous wild-type PTEN [35].
  • The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines [36].
  • The epigenetic regulation of the PDGF-B gene dictates whether TGFbeta acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma [37].
  • Glycerol and sodium 4-phenylbutyrate reduced the amount of Hsc70 expressed in glioma cells to levels found in normal astrocytes [38].
  • We found that, in the single-locus analysis, glioma risk was statistically significantly associated with three XRCC5 tSNPs (SNP1 rs828704, SNP6 rs3770502 and SNP7 rs9288516, P = 0.005, 0.042 and 0.003, respectively), one XRCC6 tSNP (SNP4 rs6519265, P = 0.044) but none of XPCC7 tSNPs [39].
  • We further show that transforming growth factor-beta (TGF-beta) up-regulates the expression of LLT1 in glioma cells [40].
  • Exogenous expression of ELMO1 and Dock180 in glioma cells with low level endogenous expression increased their migratory and invasive capacity in vitro and in brain tissue [41].
  • Ntv-a mice were injected with RCAS vectors to express PDGF-B + Bcl-2, resulting in both low- and high-grade gliomas [42].
 

Analytical, diagnostic and therapeutic context of Glioma

References

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