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Chemical Compound Review:

Pyrimidoxime [1-[3-(3-methylimidazol-1...

Synonyms: AC1NURD4, LS-132621, 69445-02-9

This record was replaced with 5489671.

Clement, J.G. et al., Garrigue, H. et al.

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Disease relevance of 1-[3-(3-methylimidazol-1-yl)propyl]-4-(nitrosomethylene)pyridine

The toxicity and efficacy of two oximes, HLö-7 and pyrimidoxime, were evaluated in mice and compared to those obtained with HI-6 [1].

High impact information on 1-[3-(3-methylimidazol-1-yl)propyl]-4-(nitrosomethylene)pyridine

HLö-7 and pyrimidoxime produced 24 h LD50 values of 356 and 291 mg/kg (i.p.), respectively [1].
Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning [2].

References

Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Clement, J.G., Hansen, A.S., Boulet, C.A. Arch. Toxicol. (1992) [Pubmed]
Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning. Garrigue, H., Maurizis, J.C., Nicolas, C., Madelmont, J.C., Godeneche, D., Hulot, T., Morge, X., Demerseman, P., Sentenac-Roumanou, H., Veyre, A. Xenobiotica (1990) [Pubmed]

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