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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

CTK3I7332     N-[4,5-dihydroxy-6- (hydroxymethyl)-2-(2,3...

Synonyms: AR-1D1945, AC1L19JM, AC1Q5O3A, 1-Adgmi, 91811-18-6
 
 
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Disease relevance of GlcNAc-Ins

  • Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) [1].
 

High impact information on GlcNAc-Ins

  • In the present study we found that a protein encoded by the M. tuberculosis open reading frame Rv1170, a homolog of Rv1082, possesses weak mycothiol conjugate amidase activity but shows substantial deacetylation activity with 1-D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins), a hypothetical mycothiol biosynthetic precursor [2].
  • The substrate specificity of MshB was compared to that of M. tuberculosis mycothiol S-conjugate amidase (Mca), a homologous enzyme having weak GlcNAc-Ins deacetylase activity [3].
  • Antisense oligonucleotides to both GlcNAc-Ins deacetylase (Rv1170) and mtr (Rv2855) mRNA affect mycobacterial growth [4].

References

  1. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). Newton, G.L., Koledin, T., Gorovitz, B., Rawat, M., Fahey, R.C., Av-Gay, Y. J. Bacteriol. (2003) [Pubmed]
  2. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. Newton, G.L., Av-Gay, Y., Fahey, R.C. J. Bacteriol. (2000) [Pubmed]
  3. Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Newton, G.L., Ko, M., Ta, P., Av-Gay, Y., Fahey, R.C. Protein Expr. Purif. (2006) [Pubmed]
  4. Differential expression of mycothiol pathway genes: are they affected by antituberculosis drugs? Hayward, D., Wiid, I., van Helden, P. IUBMB Life (2004) [Pubmed]
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