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Chemical Compound Review:

Amiclenomycin 2-amino-4-(4-amino-1- cyclohexa-2,5...

Synonyms: Amyclenomycin, SureCN4316155, NSC-246130, LS-47806, NSC246130, ...

Poetsch, M. et al., Mann, S. et al., Hotta, K. et al.

Mann, Marquet, Ploux,

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Disease relevance of NSC246130

The following kinetic parameters for the inactivation of Escherichia coli DAPA AT by amiclenomycin were derived: K(I)=2 microM and k(inact)=0.4 min(-1) [1].
Four new and two known peptide antibiotics containing amiclenomycin (Acm) have been isolated from a culture of Streptomyces venezuelae Tü 2460: L-MeIle-L-Acm (1), L-Ile-L-Acm (2), L-MeVal-L-Acm (3), L-MeIle-L-Acm-L-Gln (4), L-Ile-L-Acm-L-Gln (5) and L-Val-L-Acm-L-Gln (6) [2].
Amiclenomycin (AM) was found to be a strong inhibitor of KAPA-DAPA aminotransferase of Brevibacterium divaricatum [3].

References

Inhibition of 7,8-diaminopelargonic acid aminotransferase by amiclenomycin and analogues. Mann, S., Marquet, A., Ploux, O. Biochem. Soc. Trans. (2005) [Pubmed]
Metabolic products from microorganisms. 230. Amiclenomycin-peptides, new antimetabolites of biotin. Taxonomy, fermentation and biological properties. Poetsch, M., Zähner, H., Werner, R.G., Kern, A., Jung, G. J. Antibiot. (1985) [Pubmed]
Studies of the mode of action of amiclenomycin. Hotta, K., Kitahara, T., Okami, Y. J. Antibiot. (1975) [Pubmed]

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