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Chemical Compound Review

Pobilukast     3-[(1S,2R)-2-carboxy-2- hydroxy-1-[2-(8...

Synonyms: CHEMBL22776, SureCN125952, CHEBI:126669, SKF-104353, SKF104353, ...
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High impact information on SKF104353

  • Administration of the specific peptidoleukotriene receptor antagonist SKF104353 to 20 week old MRL-lpr/lpr mice significantly improved both GFR and CPAH, whereas this agent had no effect of renal hemodynamics in MRL(-)+/+ controls [1].
  • Pretreatment with two structurally unrelated LTD4 receptor antagonists, LY171883 and SKF104353 (10 microM), fully prevented the increase in CPP and LVEDP [2].
  • Further, a reduced degree of smooth muscle contraction in the presence of the leukotriene receptor antagonist SKF104353 suggested that this effect was mediated by leukotriene metabolites [3].


  1. Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. Spurney, R.F., Ruiz, P., Pisetsky, D.S., Coffman, T.M. Kidney Int. (1991) [Pubmed]
  2. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. Sala, A., Rossoni, G., Buccellati, C., Berti, F., Folco, G., Maclouf, J. Br. J. Pharmacol. (1993) [Pubmed]
  3. Identification of PLA(2) and alpha-neurotoxin proteins in the venom of Pseudonaja affinis (dugite). Judge, R.K., Henry, P.J., d'Aprile, A.C., Lynch, D., Jelinek, G.A., Wilce, M.C., Wilce, J.A. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
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