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MeSH Review

Muscle, Smooth

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Disease relevance of Muscle, Smooth


Psychiatry related information on Muscle, Smooth

  • NmU was first isolated based on its ability to contract rat uterine smooth-muscle (hence the suffix "U") and has since been implicated in the regulation of smooth-muscle contraction, blood pressure and local blood flow, ion transport in the gut, stress responses, cancer, gastric acid secretion, pronociception, and feeding behavior [6].
  • 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction [7].
  • A recent report has suggested that the interaction between the head and the rod region of smooth muscle myosin at S2 is important for the phosphorylation-mediated regulation of myosin motor activity [Trybus, K. M., Freyzon, Y., Faust, L. Z., and Sweeney, H. L. (1997) Proc. Natl. Acad. Sci. U.S.A. 74, 48-52] [8].
  • The results suggest that both inhibition of water absorption and reduced circular smooth muscle activity may be important factors in castor oil- and magnesium sulfate-induced catharsis [9].
  • 4. In rat tail artery, the effects (dose-response and time-response curves) of cirazoline and TL99 on intracellular Ca2+ levels in freshly dispersed single smooth muscle cells were comparable with those obtained with organ bath studies of ring preparations of artery [10].

High impact information on Muscle, Smooth

  • Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells [11].
  • In view of the importance of NO as a modulator of vascular tone under basal conditions and in disease and chronic inflammation, we critically review the evidence that transport of L-arginine and glucose in endothelial and smooth muscle cells is modulated by bacterial endotoxin, proinflammatory cytokines, and atherogenic lipids [11].
  • TRP-related channel proteins are found in a variety of organisms, tissues, and cell types, including nonexcitable, smooth muscle, and neuronal cells [12].
  • After this, the roles of the extracellular matrix, integrins, and the smooth muscle cytoskeleton are reviewed, with emphasis on short-term signaling mechanisms [13].
  • Two KIR6.x genes and two SUR genes have been identified, and combinations of subunits give rise to KATP channel subtypes found in pancreatic beta-cells, neurons, and cardiac, skeletal, and smooth muscle [14].

Chemical compound and disease context of Muscle, Smooth


Biological context of Muscle, Smooth


Anatomical context of Muscle, Smooth


Associations of Muscle, Smooth with chemical compounds

  • To exclude the possibility that heparin had any direct effect on airway smooth muscle, bronchial provocation with histamine was induced in five subjects on two further days after pretreatment with either heparin or placebo [30].
  • We then studied the smooth-muscle relaxant responses to stimulation by an electrical field and to nitric oxide [31].
  • In seven patients with cough, studies revealed a more severe obstructive pattern that appeared to be the result of increased large-airway resistance, and the patients' response to isoproterenol indicated that contraction of bronchial smooth muscle may have been principally responsible [32].
  • This non-anticoagulant action of heparin is more likely to be related to a modulation of mediator release than to a direct effect on smooth muscle [30].
  • Venous and arterial smooth muscle cells and skin fibroblasts synthesized PGI2 from exogenous arachidonic acid, but they did not synthesize a significant amount of PGI2 when treated with histamine [33].

Gene context of Muscle, Smooth


Analytical, diagnostic and therapeutic context of Muscle, Smooth


  1. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. Giaid, A., Yanagisawa, M., Langleben, D., Michel, R.P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W.P., Stewart, D.J. N. Engl. J. Med. (1993) [Pubmed]
  2. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamoto, T. Nature (1991) [Pubmed]
  3. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Ferns, G.A., Raines, E.W., Sprugel, K.H., Motani, A.S., Reidy, M.A., Ross, R. Science (1991) [Pubmed]
  4. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Miles, S.A., Martínez-Maza, O., Rezai, A., Magpantay, L., Kishimoto, T., Nakamura, S., Radka, S.F., Linsley, P.S. Science (1992) [Pubmed]
  5. Pathogenesis of arteritis of SL/Ni mice. Possible lytic effect of anti-gp70 antibodies on vascular smooth muscle cells. Miyazawa, M., Nose, M., Kawashima, M., Kyogoku, M. J. Exp. Med. (1987) [Pubmed]
  6. Neuromedin U and its receptors: structure, function, and physiological roles. Brighton, P.J., Szekeres, P.G., Willars, G.B. Pharmacol. Rev. (2004) [Pubmed]
  7. 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction. Hewawasam, P., Fan, W., Ding, M., Flint, K., Cook, D., Goggins, G.D., Myers, R.A., Gribkoff, V.K., Boissard, C.G., Dworetzky, S.I., Starrett, J.E., Lodge, N.J. J. Med. Chem. (2003) [Pubmed]
  8. Registration of the rod is not critical for the phosphorylation-dependent regulation of smooth muscle myosin. Ikebe, M., Yamada, M., Mabuchi, K., Kambara, T., Ikebe, R. Biochemistry (1999) [Pubmed]
  9. Inhibitory actions of laxatives on motility and water and electrolyte transport in the gastrointestinal tract. Stewart, J.J., Gaginella, T.S., Olsen, W.A., Bass, P. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  10. The effects of alpha-adrenoceptor agonists on intracellular Ca2+ levels in freshly dispersed single smooth muscle cells from rat tail artery. Li, X.F., Kargacin, M.E., Triggle, C.R. Br. J. Pharmacol. (1993) [Pubmed]
  11. Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Mann, G.E., Yudilevich, D.L., Sobrevia, L. Physiol. Rev. (2003) [Pubmed]
  12. TRP channel proteins and signal transduction. Minke, B., Cook, B. Physiol. Rev. (2002) [Pubmed]
  13. Signaling mechanisms underlying the vascular myogenic response. Davis, M.J., Hill, M.A. Physiol. Rev. (1999) [Pubmed]
  14. Toward understanding the assembly and structure of KATP channels. Aguilar-Bryan, L., Clement, J.P., Gonzalez, G., Kunjilwar, K., Babenko, A., Bryan, J. Physiol. Rev. (1998) [Pubmed]
  15. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. Eddahibi, S., Humbert, M., Fadel, E., Raffestin, B., Darmon, M., Capron, F., Simonneau, G., Dartevelle, P., Hamon, M., Adnot, S. J. Clin. Invest. (2001) [Pubmed]
  16. Specific receptors for leukotriene C4 on a smooth muscle cell line. Krilis, S., Lewis, R.A., Corey, E.J., Austen, K.F. J. Clin. Invest. (1983) [Pubmed]
  17. Leukotrienes in acetylcholine-induced contraction of esophageal circular smooth muscle in experimental esophagitis. Kim, N., Sohn, U.D., Mangannan, V., Rich, H., Jain, M.K., Behar, J., Biancani, P. Gastroenterology (1997) [Pubmed]
  18. Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination. Annese, V., Janssens, J., Vantrappen, G., Tack, J., Peeters, T.L., Willemse, P., Van Cutsem, E. Gastroenterology (1992) [Pubmed]
  19. Severe idiopathic constipation is associated with a distinctive abnormality of the colonic myenteric plexus. Krishnamurthy, S., Schuffler, M.D., Rohrmann, C.A., Pope, C.E. Gastroenterology (1985) [Pubmed]
  20. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Quayle, J.M., Nelson, M.T., Standen, N.B. Physiol. Rev. (1997) [Pubmed]
  21. Vascular tissue plasminogen activator and the development of coronary artery disease in heart-transplant recipients. Labarrere, C.A., Pitts, D., Nelson, D.R., Faulk, W.P. N. Engl. J. Med. (1995) [Pubmed]
  22. Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Iafrati, M.D., Karas, R.H., Aronovitz, M., Kim, S., Sullivan, T.R., Lubahn, D.B., O'Donnell, T.F., Korach, K.S., Mendelsohn, M.E. Nat. Med. (1997) [Pubmed]
  23. Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin molecules. Craig, R., Smith, R., Kendrick-Jones, J. Nature (1983) [Pubmed]
  24. The essential light chains constitute part of the active site of smooth muscle myosin. Okamoto, Y., Sekine, T., Grammer, J., Yount, R.G. Nature (1986) [Pubmed]
  25. Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts. Baenziger, N.L., Becherer, P.R., Majerus, P.W. Cell (1979) [Pubmed]
  26. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Foo, S.S., Turner, C.J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., Adams, R.H. Cell (2006) [Pubmed]
  27. Synemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle. Granger, B.L., Lazarides, E. Cell (1980) [Pubmed]
  28. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Soares, M.P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S.T., Colvin, R.B., Choi, A.M., Poss, K.D., Bach, F.H. Nat. Med. (1998) [Pubmed]
  29. Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor. Coughlin, S.R., Moskowitz, M.A., Zetter, B.R., Antoniades, H.N., Levine, L. Nature (1980) [Pubmed]
  30. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. Ahmed, T., Garrigo, J., Danta, I. N. Engl. J. Med. (1993) [Pubmed]
  31. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. Rajfer, J., Aronson, W.J., Bush, P.A., Dorey, F.J., Ignarro, L.J. N. Engl. J. Med. (1992) [Pubmed]
  32. Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma. McFadden, E.R. N. Engl. J. Med. (1975) [Pubmed]
  33. Regulation of histamine-mediated prostacyclin synthesis in cultured human vascular endothelial cells. Baenziger, N.L., Fogerty, F.J., Mertz, L.F., Chernuta, L.F. Cell (1981) [Pubmed]
  34. Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma. Libby, P., Warner, S.J., Salomon, R.N., Birinyi, L.K. N. Engl. J. Med. (1988) [Pubmed]
  35. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Koyama, H., Raines, E.W., Bornfeldt, K.E., Roberts, J.M., Ross, R. Cell (1996) [Pubmed]
  36. Cell transformation by the superoxide-generating oxidase Mox1. Suh, Y.A., Arnold, R.S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A.B., Griendling, K.K., Lambeth, J.D. Nature (1999) [Pubmed]
  37. Identification of receptors for neuromedin U and its role in feeding. Howard, A.D., Wang, R., Pong, S.S., Mellin, T.N., Strack, A., Guan, X.M., Zeng, Z., Williams, D.L., Feighner, S.D., Nunes, C.N., Murphy, B., Stair, J.N., Yu, H., Jiang, Q., Clements, M.K., Tan, C.P., McKee, K.K., Hreniuk, D.L., McDonald, T.P., Lynch, K.R., Evans, J.F., Austin, C.P., Caskey, C.T., Van der Ploeg, L.H., Liu, Q. Nature (2000) [Pubmed]
  38. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Marrero, M.B., Schieffer, B., Paxton, W.G., Heerdt, L., Berk, B.C., Delafontaine, P., Bernstein, K.E. Nature (1995) [Pubmed]
  39. The nucleotide sequence and the tissue-specific expression of Drosophila c-src. Simon, M.A., Drees, B., Kornberg, T., Bishop, J.M. Cell (1985) [Pubmed]
  40. Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Kume, H., Takai, A., Tokuno, H., Tomita, T. Nature (1989) [Pubmed]
  41. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Shimizu, K., Sugiyama, S., Aikawa, M., Fukumoto, Y., Rabkin, E., Libby, P., Mitchell, R.N. Nat. Med. (2001) [Pubmed]
  42. Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Goedert, M., Hunter, J.C., Ninkovic, M. Nature (1984) [Pubmed]
  43. Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney. Marin-Grez, M., Fleming, J.T., Steinhausen, M. Nature (1986) [Pubmed]
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