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Gene Review

CYSLTR1  -  cysteinyl leukotriene receptor 1

Homo sapiens

Synonyms: CYSLT1, CYSLT1R, CYSLTR, CysLT(1), CysLT1, ...
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Disease relevance of CYSLTR1


High impact information on CYSLTR1


Chemical compound and disease context of CYSLTR1


Biological context of CYSLTR1


Anatomical context of CYSLTR1


Associations of CYSLTR1 with chemical compounds


Physical interactions of CYSLTR1


Regulatory relationships of CYSLTR1


Other interactions of CYSLTR1


Analytical, diagnostic and therapeutic context of CYSLTR1


  1. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. Zhang, J., Migita, O., Koga, M., Shibasaki, M., Arinami, T., Noguchi, E. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2006) [Pubmed]
  2. The mast cell and the cysteinyl leukotrienes. Austen, K.F. Novartis Found. Symp. (2005) [Pubmed]
  3. Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. Ohd, J.F., Nielsen, C.K., Campbell, J., Landberg, G., Löfberg, H., Sjölander, A. Gastroenterology (2003) [Pubmed]
  4. 927T>C polymorphism of the cysteinyl-leukotriene type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis. Arriba-Mendez, S., Sanz, C., Isidoro-Garcia, M., Davild, I., Laffond, E., Horeno, E., Avila, C., Lorente, F. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2006) [Pubmed]
  5. Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. Bautz, F., Denzlinger, C., Kanz, L., Möhle, R. Blood (2001) [Pubmed]
  6. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Lynch, K.R., O'Neill, G.P., Liu, Q., Im, D.S., Sawyer, N., Metters, K.M., Coulombe, N., Abramovitz, M., Figueroa, D.J., Zeng, Z., Connolly, B.M., Bai, C., Austin, C.P., Chateauneuf, A., Stocco, R., Greig, G.M., Kargman, S., Hooks, S.B., Hosfield, E., Williams, D.L., Ford-Hutchinson, A.W., Caskey, C.T., Evans, J.F. Nature (1999) [Pubmed]
  7. Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist. Reiss, T.F., Hill, J.B., Harman, E., Zhang, J., Tanaka, W.K., Bronsky, E., Guerreiro, D., Hendeles, L. Thorax (1997) [Pubmed]
  8. Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. Nettis, E., Colanardi, M.C., Paradiso, M.T., Ferrannini, A. Clin. Exp. Allergy (2004) [Pubmed]
  9. Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs. Nabe, T., Yamashita, K., Miura, M., Kawai, T., Kohno, S. Clin. Exp. Allergy (2002) [Pubmed]
  10. Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. Ruck, L.M., Rizzo, C.A., Anthes, J.C., Eckel, S., Egan, R.W., Cuss, F.M., Hey, J.A. Life Sci. (2001) [Pubmed]
  11. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pillai, S.G., Cousens, D.J., Barnes, A.A., Buckley, P.T., Chiano, M.N., Hosking, L.K., Cameron, L.A., Fling, M.E., Foley, J.J., Green, A., Sarau, H.M., Schmidt, D.B., Sprankle, C.S., Blumenthal, M.N., Vestbo, J., Kennedy-Wilson, K., Wixted, W.E., Wagner, M.J., Anderson, W.H., Ignar, D.M. Pharmacogenetics (2004) [Pubmed]
  12. Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils. Mita, H., Hasegawa, M., Saito, H., Akiyama, K. Clin. Exp. Allergy (2001) [Pubmed]
  13. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Choi, J.H., Park, H.S., Oh, H.B., Lee, J.H., Suh, Y.J., Park, C.S., Shin, H.D. Hum. Genet. (2004) [Pubmed]
  14. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. Thivierge, M., Stankova, J., Rola-Pleszczynski, M. J. Allergy Clin. Immunol. (2006) [Pubmed]
  15. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. Shirasaki, H., Kanaizumi, E., Watanabe, K., Matsui, T., Sato, J., Narita, S., Rautiainen, M., Himi, T. Clin. Exp. Allergy (2002) [Pubmed]
  16. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. Jonsson, E.W. Acta physiologica Scandinavica. Supplementum. (1998) [Pubmed]
  17. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. Nielsen, C.K., Campbell, J.I., Ohd, J.F., Mörgelin, M., Riesbeck, K., Landberg, G., Sjölander, A. Cancer Res. (2005) [Pubmed]
  18. Current treatment of asthma--focus on leukotrienes. Crowther, S.D., Rees, P.J. Expert opinion on pharmacotherapy. (2000) [Pubmed]
  19. Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma. Parameswaran, K., Liang, H., Fanat, A., Watson, R., Snider, D.P., O'Byrne, P.M. J. Allergy Clin. Immunol. (2004) [Pubmed]
  20. Characterization of interleukin-4-stimulated nasal polyp fibroblasts. Steinke, J.W., Crouse, C.D., Bradley, D., Hise, K., Lynch, K., Kountakis, S.E., Borish, L. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  21. Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. Perng, D.W., Wu, Y.C., Chang, K.T., Wu, M.T., Chiou, Y.C., Su, K.C., Perng, R.P., Lee, Y.C. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  22. Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis. Figueroa, D.J., Borish, L., Baramki, D., Philip, G., Austin, C.P., Evans, J.F. Clin. Exp. Allergy (2003) [Pubmed]
  23. Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. de Alarc??n, A., Steinke, J.W., Caughey, R., Barekzi, E., Hise, K., Gross, C.W., Han, J.K., Borish, L. American journal of rhinology. (2006) [Pubmed]
  24. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. Espinosa, K., Bossé, Y., Stankova, J., Rola-Pleszczynski, M. J. Allergy Clin. Immunol. (2003) [Pubmed]
  25. Genetic markers for differentiating aspirin-hypersensitivity. Kim, S.H., Park, H.S. Yonsei Med. J. (2006) [Pubmed]
  26. Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. Bandeira-Melo, C., Woods, L.J., Phoofolo, M., Weller, P.F. J. Exp. Med. (2002) [Pubmed]
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