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Chemical Compound Review

Dipterine     2-(1H-indol-3-yl)-N-methyl- ethanamine

Synonyms: CHEMBL348588, SureCN379409, AG-A-50639, CHEBI:28136, HMDB04370, ...
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High impact information on Dipterine

  • An effective biotransformation of N-methyltryptamine was also demonstrated with surface cultures of Psilocybe semilanceata [1].
  • When C14-labelled N-methyltryptamine was administered by intravenous injection to rabbits, C14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen [2].
  • Partially purified rabbit lung N-methyltransferase (NMT) was used in an in vitro assay to screen various amines and substrate analogs as potential inhibitors, N-Methyltryptamine (NMeT, 10(-3 M) and 14C-S-adenosyl-L-methionine (14C-SAM, 2.5 X 10(-5) M) were used as substrates to form 14C-N, N-dimethyltryptamine (14C-DMT) [3].


  1. Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe. Gartz, J. J. Basic Microbiol. (1989) [Pubmed]
  2. The biosynthesis of dimethyltryptamine in vivo. Mandel, L.R., Prasad, R., Lopez-Ramos, B., Walker, R.W. Res. Commun. Chem. Pathol. Pharmacol. (1977) [Pubmed]
  3. Search for new treatment approaches in schizophrenia: in vitro studies of potential N-methyltransferase inhibitors. Domino, E.F. Archives internationales de pharmacodynamie et de thérapie. (1976) [Pubmed]
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