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Chemical Compound Review:

Butylphthalide 3-butyl-3H-isobenzofuran-1-one

Synonyms: CHEMBL248594, SureCN716879, CCRIS 7107, AG-C-84057, ACMC-20mrif, ...

Tsi, D. et al., Zhao, C. et al., Xu, H.L. et al., Zhang, Y. et al., Xu, H.L. et al., et al.

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Disease relevance of CCRIS 7107

2-(1-Hydroxypentyl)-benzoate (dl-PHPB), a derivate of 3-n-butylphthalide (dl-NBP), is a novel drug candidate used for treatment of cerebral ischemia [1].

High impact information on CCRIS 7107

3-n-Butylphthalide exhibited linear pharmacokinetics after intravenous administration to rabbits over the dose range 1-10 mg/kg [2].
AIM: To evaluate the degree of neutrophil infiltration into ischemic tissue after transient focal cerebral ischemia, and to examine the effects of chiral 3-n-butylphthalide (NBP) on this inflammatory process [3].
Effects of 3-n-butylphthalide on production of vasoactive substances by cerebral and aortic endothelial cells [4].

Biological context of CCRIS 7107

Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats [5].

Analytical, diagnostic and therapeutic context of CCRIS 7107

Analysis of an ethereal extract of the aqueous extract of celery by thin layer chromatography (TLC) with two different solvent systems showed that the extract did not contain 3-n-butylphthalide (BuPh), a unique compound in celery that has previously been reported to have lipid-lowering action [6].
Determination of 3-n-butylphthalide in rabbit plasma by HPLC with fluorescence detection and its application in pharmacokinetic study [2].

References

2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia. Zhang, Y., Wang, L., Li, J., Wang, X.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
Determination of 3-n-butylphthalide in rabbit plasma by HPLC with fluorescence detection and its application in pharmacokinetic study. Zhao, C., He, Z., Cui, S., Zhang, R. Biomed. Chromatogr. (2003) [Pubmed]
Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats. Xu, H.L., Feng, Y.P. Acta Pharmacol. Sin. (2000) [Pubmed]
Effects of 3-n-butylphthalide on production of vasoactive substances by cerebral and aortic endothelial cells. Xu, H.L., Feng, Y.P. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats. Chang, Q., Wang, X.L. Acta Pharmacol. Sin. (2003) [Pubmed]
Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet. Tsi, D., Das, N.P., Tan, B.K. Planta Med. (1995) [Pubmed]

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