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Chemical Compound Review

AC1LCEQ8     1-pyren-1-ylpyrrole-2,5-dione

Synonyms: ACMC-209jo6, P7908_SIGMA, ANW-29764, KB-78996, CTK4I5822, ...
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Disease relevance of ZINC00120631


High impact information on ZINC00120631

  • Fluorescence lifetime, anisotropy, and quenching measurements of N-(1-pyrenyl)-maleimide (PMal) covalently bound to Cys26 indicate local structural changes around PMal in the amino-terminal domain in response to oxidative modification of methionine residues in the carboxyl-terminal domain [2].
  • Furthermore, intact mitochondria were labelled with the sulfhydryl-alkylating agents N-[14C]ethylmaleimide, eosin-5-maleimide and N-(1-pyrenyl)-maleimide [3].


  1. Fluorescence polarization study of the alpha-ketoglutarate dehydrogenase complex from Escherichia coli. Waskiewicz, D.E., Hammes, G.G. Biochemistry (1982) [Pubmed]
  2. Loss of conformational stability in calmodulin upon methionine oxidation. Gao, J., Yin, D.H., Yao, Y., Sun, H., Qin, Z., Schöneich, C., Williams, T.D., Squier, T.C. Biophys. J. (1998) [Pubmed]
  3. Characterization of SH groups in porin of bovine heart mitochondria. Porin cysteines are localized in the channel walls. De Pinto, V., al Jamal, J.A., Benz, R., Genchi, G., Palmieri, F. Eur. J. Biochem. (1991) [Pubmed]
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