Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Antigorite magnesium; silicic acid; hydrate

Synonyms: Zermattite, AC1O3S1O, 12135-86-3, Antigorite (Mg3H2(SiO4)2.H2O)

Jung, H. et al., Woźniak, H. et al., Marsh, J.P. et al., Woodworth, C.D. et al.

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Disease relevance of Antigorite

Nonfibrous analogues of each material (riebeckite, antigorite, and glass particles) failed to produce metaplasia [1].
Here we show that dehydration of antigorite serpentinite under stress results in faults delineated by ultrafine-grained solid reaction products formed during dehydration [2].
Particularly the frequency of mesothelioma (5-85%) was related to the number of antigorite fibres longer than 5 microns [3].

High impact information on Antigorite

Stimulation of ODC was not observed when nonfibrous analogues (riebeckite, antigorite, and glass particles) were used [4].

References

Induction of squamous metaplasia in organ cultures of hamster trachea by naturally occurring and synthetic fibers. Woodworth, C.D., Mossman, B.T., Craighead, J.E. Cancer Res. (1983) [Pubmed]
Intermediate-depth earthquake faulting by dehydration embrittlement with negative volume change. Jung, H., Green II, H.W., Dobrzhinetskaya, L.F. Nature (2004) [Pubmed]
Experimental carcinogenicity and mutagenicity of non-asbestos natural fibres--preliminary report. Woźniak, H., Wiecek, E., Stetkiewicz, J., Wyszyńska, K. Polish journal of occupational medicine and environmental health. (1993) [Pubmed]
Mechanisms of induction of ornithine decarboxylase activity in tracheal epithelial cells by asbestiform minerals. Marsh, J.P., Mossman, B.T. Cancer Res. (1988) [Pubmed]

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