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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Mesothelioma


Psychiatry related information on Mesothelioma


High impact information on Mesothelioma


Chemical compound and disease context of Mesothelioma


Biological context of Mesothelioma


Anatomical context of Mesothelioma


Gene context of Mesothelioma

  • Homozygous deletion of the INK4a/ARF locus is common in human mesothelioma and may result in the loss of p14(ARF) and the inactivation of p53 [23].
  • All malignant mesothelioma cell lines tested also spontaneously expressed M-CSF transcripts [24].
  • Intrapleural injections of recombinant human IFN-gamma have shown some efficacy in reducing tumor growth in early stages of diffuse malignant mesothelioma (DMM) [25].
  • This finding indicates that these nonmalignant isolates may retain properties of reactive mesothelial cells and suggests that targets in addition to COX2 may be involved in the antiproliferative response of mesothelioma cell lines [26].
  • Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma [27].
  • Early passages of 12 mesothelioma cell cultures from ascites developed in RCF1-exposed Nf2(+/-) mice demonstrated frequent inactivation by deletion of genes at the Ink4 locus, and low rate of Trp53 point and insertion mutations [28].
  • Analysis in terms of histologic type showed that serum levels of N-ERC/mesothelin were elevated in epithelioid type mesothelioma, especially [29].

Analytical, diagnostic and therapeutic context of Mesothelioma

  • These data show that intracavitary IFN-beta gene therapy using an adenoviral vector provides strong CD8(+) T-cell-mediated antitumor effects in murine models of mesothelioma and suggest that this may be a promising strategy for the treatment of localized tumors such as mesothelioma or ovarian cancer in humans [30].
  • To further analyze the efficacy of hsp-65 immunotherapy in clinically relevant models of localized cancer, immunocompetent mice bearing i.p. murine mesothelioma were treated with four i.p. doses of a cationic lipid complexed with plasmid DNA (pDNA) containing hsp65, LacZ, or a null plasmid [31].
  • On Western blot analysis, antibodies raised against the anionic GST purified from mesothelioma detect protein of Mr approximately 25,000 in extracts of both normal kidney and tumors containing anionic GST activity but not in extracts of human liver that did not contain detectable anionic activity [32].
  • We report the results of this investigation: (a) DNA and protein analyses revealed SV40 sequences and SV40 large T antigen expression in 10 of 12 mesotheliomas tested (83%); and (b) electron microscopy demonstrated variable amounts of asbestos fibers in 5 (71%) of 7 corresponding lung tissues available for analysis [33].
  • For investigation of early mesothelial reactions associated with the development of mesotheliomas, C57BL/6 mice were given intraperitoneal injections of 200 micrograms of short or long crocidolite asbestos fibers, toxic silica particles, or nontoxic titanium dioxide particles [34].


  1. Simian virus-40 large-T antigen binds p53 in human mesotheliomas. Carbone, M., Rizzo, P., Grimley, P.M., Procopio, A., Mew, D.J., Shridhar, V., de Bartolomeis, A., Esposito, V., Giuliano, M.T., Steinberg, S.M., Levine, A.S., Giordano, A., Pass, H.I. Nat. Med. (1997) [Pubmed]
  2. Enzyme pathology of human mesotheliomas. Greengard, O., Head, J.F., Chahinian, A.P., Goldberg, S.L. J. Natl. Cancer Inst. (1987) [Pubmed]
  3. Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma. Kratzke, R.A., Otterson, G.A., Lincoln, C.E., Ewing, S., Oie, H., Geradts, J., Kaye, F.J. J. Natl. Cancer Inst. (1995) [Pubmed]
  4. Influence of age on induction of mammary tumors by diethylstilbestrol in C3H/HeN mice with low murine mammary tumor virus titer. Greenman, D.L., Highman, B., Chen, J.J., Schieferstein, G.J., Norvell, M.J. J. Natl. Cancer Inst. (1986) [Pubmed]
  5. Hepatocyte growth factor/scatter factor and its receptor c-Met are overexpressed and associated with an increased microvessel density in malignant pleural mesothelioma. Tolnay, E., Kuhnen, C., Wiethege, T., König, J.E., Voss, B., Müller, K.M. J. Cancer Res. Clin. Oncol. (1998) [Pubmed]
  6. Absence of BCL10 mutations in human malignant mesothelioma. Apostolou, S., De Rienzo, A., Murthy, S.S., Jhanwar, S.C., Testa, J.R. Cell (1999) [Pubmed]
  7. The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Park, S., Schalling, M., Bernard, A., Maheswaran, S., Shipley, G.C., Roberts, D., Fletcher, J., Shipman, R., Rheinwald, J., Demetri, G. Nat. Genet. (1993) [Pubmed]
  8. The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas. De Luca, A., Baldi, A., Esposito, V., Howard, C.M., Bagella, L., Rizzo, P., Caputi, M., Pass, H.I., Giordano, G.G., Baldi, F., Carbone, M., Giordano, A. Nat. Med. (1997) [Pubmed]
  9. Chrysotile, tremolite, and mesothelioma. McDonald, J.C., McDonald, A.D. Science (1995) [Pubmed]
  10. Membranoproliferative glomerulonephritis following gemcitabine and vinorelbine chemotherapy for peritoneal mesothelioma. Fracasso, P.M., Tan, B.R., Grieff, M., Stephenson, J., Liapis, H., Umbeck, N.L., Von Hoff, D.D., Rowinsky, E.K. J. Natl. Cancer Inst. (1999) [Pubmed]
  11. Early diagnosis and monitoring of transplanted human malignant mesothelioma by serum hyaluronic acid. Roboz, J., Chahinian, A.P., Holland, J.F., Silides, D., Szrajer, L. J. Natl. Cancer Inst. (1989) [Pubmed]
  12. Mesothelioma in child with prenatal exposure to isoniazid. Tuman, K.J., Chilcote, R.R., Berkow, R.I., Moohr, J.W. Lancet (1980) [Pubmed]
  13. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Chang, K., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  14. Posttranscriptional regulation of urokinase receptor mRNA: identification of a novel urokinase receptor mRNA binding protein in human mesothelioma cells. Shetty, S., Kumar, A., Idell, S. Mol. Cell. Biol. (1997) [Pubmed]
  15. Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas. Shukla, A., Miller, J.M., Cason, C., Sayan, M., MacPherson, M.B., Beuschel, S.L., Hillegass, J., Vacek, P.M., Pass, H.I., Mossman, B.T. Clin. Cancer Res. (2013) [Pubmed]
  16. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. He, B., Lee, A.Y., Dadfarmay, S., You, L., Xu, Z., Reguart, N., Mazieres, J., Mikami, I., McCormick, F., Jablons, D.M. Cancer Res. (2005) [Pubmed]
  17. Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma. Jagadeeswaran, R., Ma, P.C., Seiwert, T.Y., Jagadeeswaran, S., Zumba, O., Nallasura, V., Ahmed, S., Filiberti, R., Paganuzzi, M., Puntoni, R., Kratzke, R.A., Gordon, G.J., Sugarbaker, D.J., Bueno, R., Janamanchi, V., Bindokas, V.P., Kindler, H.L., Salgia, R. Cancer Res. (2006) [Pubmed]
  18. p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Ponce-Castañeda, M.V., Lee, M.H., Latres, E., Polyak, K., Lacombe, L., Montgomery, K., Mathew, S., Krauter, K., Sheinfeld, J., Massague, J. Cancer Res. (1995) [Pubmed]
  19. Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression. Ramos-Nino, M.E., Timblin, C.R., Mossman, B.T. Cancer Res. (2002) [Pubmed]
  20. Chromosomal translocations with specific breakpoints in asbestos-induced rat mesotheliomas. Libbus, B.L., Craighead, J.E. Cancer Res. (1988) [Pubmed]
  21. A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression. Manning, C.B., Cummins, A.B., Jung, M.W., Berlanger, I., Timblin, C.R., Palmer, C., Taatjes, D.J., Hemenway, D., Vacek, P., Mossman, B.T. Cancer Res. (2002) [Pubmed]
  22. Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. Campa, M.J., Schreiber, G., Bepler, G., Bishop, M.J., McNutt, R.W., Chang, K.J., Patz, E.F. Cancer Res. (1996) [Pubmed]
  23. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. Yang, C.T., You, L., Yeh, C.C., Chang, J.W., Zhang, F., McCormick, F., Jablons, D.M. J. Natl. Cancer Inst. (2000) [Pubmed]
  24. Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro. Demetri, G.D., Zenzie, B.W., Rheinwald, J.G., Griffin, J.D. Blood (1989) [Pubmed]
  25. Human malignant mesothelioma cell growth: activation of janus kinase 2 and signal transducer and activator of transcription 1alpha for inhibition by interferon-gamma. Buard, A., Vivo, C., Monnet, I., Boutin, C., Pilatte, Y., Jaurand, M.C. Cancer Res. (1998) [Pubmed]
  26. Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. Marrogi, A., Pass, H.I., Khan, M., Metheny-Barlow, L.J., Harris, C.C., Gerwin, B.I. Cancer Res. (2000) [Pubmed]
  27. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Hirvonen, A., Pelin, K., Tammilehto, L., Karjalainen, A., Mattson, K., Linnainmaa, K. Cancer Res. (1995) [Pubmed]
  28. Clinico-pathological features and somatic gene alterations in refractory ceramic fibre-induced murine mesothelioma reveal mineral fibre-induced mesothelioma identities. Andujar, P., Lecomte, C., Renier, A., Fleury-Feith, J., Kheuang, L., Daubriac, J., Janin, A., Jaurand, M.C. Carcinogenesis (2007) [Pubmed]
  29. Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma. Shiomi, K., Hagiwara, Y., Sonoue, K., Segawa, T., Miyashita, K., Maeda, M., Izumi, H., Masuda, K., Hirabayashi, M., Moroboshi, T., Yoshiyama, T., Ishida, A., Natori, Y., Inoue, A., Kobayashi, M., Sakao, Y., Miyamoto, H., Takahashi, K., Hino, O. Clin. Cancer Res. (2008) [Pubmed]
  30. Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Odaka, M., Sterman, D.H., Wiewrodt, R., Zhang, Y., Kiefer, M., Amin, K.M., Gao, G.P., Wilson, J.M., Barsoum, J., Kaiser, L.R., Albelda, S.M. Cancer Res. (2001) [Pubmed]
  31. Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models. Lanuti, M., Rudginsky, S., Force, S.D., Lambright, E.S., Siders, W.M., Chang, M.Y., Amin, K.M., Kaiser, L.R., Scheule, R.K., Albelda, S.M. Cancer Res. (2000) [Pubmed]
  32. Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines. Shea, T.C., Kelley, S.L., Henner, W.D. Cancer Res. (1988) [Pubmed]
  33. A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas. Testa, J.R., Carbone, M., Hirvonen, A., Khalili, K., Krynska, B., Linnainmaa, K., Pooley, F.D., Rizzo, P., Rusch, V., Xiao, G.H. Cancer Res. (1998) [Pubmed]
  34. Acute injury and regeneration of the mesothelium in response to asbestos fibers. Moalli, P.A., MacDonald, J.L., Goodglick, L.A., Kane, A.B. Am. J. Pathol. (1987) [Pubmed]
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