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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Thr-Phe     (2R)-2-[[(2R,3R)-2-amino-3- hydroxy...

Synonyms: AC1O52X7
 
 
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High impact information on Thr-Phe

  • Thus, the Thr-Phe motif in the Pre-SH2 domain plays a critical role in SOCS-3-mediated inhibition of the IL-4-dependent Jak-Stat signaling, likely by regulating the mode of SOCS-Jak interaction [1].

References

  1. Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling. Haque, S.J., Harbor, P.C., Williams, B.R. J. Biol. Chem. (2000) [Pubmed]
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