Gene Review:
Il4 - interleukin 4
Mus musculus
Synonyms:
B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, BSF-1, IGG1 induction factor, ...
- Probabilistic regulation of IL-4 production in Th2 cells: accessibility at the Il4 locus. Guo, L., Hu-Li, J., Paul, W.E. Immunity (2004)
- Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Ko, K.S., Lee, M., Koh, J.J., Kim, S.W. Mol. Ther. (2001)
- Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M.C., Bluethmann, H., Köhler, G. Nature (1993)
- Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Ferrick, D.A., Schrenzel, M.D., Mulvania, T., Hsieh, B., Ferlin, W.G., Lepper, H. Nature (1995)
- Essential role of Stat6 in IL-4 signalling. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., Akira, S. Nature (1996)
- The beneficial effects of treatment with tamoxifen and anti-oestradiol antibody on experimental systemic lupus erythematosus are associated with cytokine modulations. Dayan, M., Zinger, H., Kalush, F., Mor, G., Amir-Zaltzman, Y., Kohen, F., Sthoeger, Z., Mozes, E. Immunology (1997)
- Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines. Kawakami, K., Hossain Qureshi, M., Zhang, T., Koguchi, Y., Xie, Q., Kurimoto, M., Saito, A. Cell. Immunol. (1999)
- Intergenic transcription is not required in Th2 cells to maintain histone acetylation and transcriptional permissiveness at the Il4-Il13 locus. Baguet, A., Sun, X., Arroll, T., Krumm, A., Bix, M. J. Immunol. (2005)
- Profiles of cytokine mRNAs in the skin and lymph nodes of SENCAR mice treated epicutaneously with dibenzo[a,l]pyrene or dimethylbenz[a]anthracene reveal a direct correlation between carcinogen-induced contact hypersensitivity and epidermal hyperplasia. Casale, G.P., Cheng, Z., Liu, J., Cavalieri, E.L., Singhal, M. Mol. Carcinog. (2000)
- Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-gamma production in vitro. Moynihan, J.A., Callahan, T.A., Kelley, S.P., Campbell, L.M. Cell. Immunol. (1998)
- Lymphokine control of in vivo immunoglobulin isotype selection. Finkelman, F.D., Holmes, J., Katona, I.M., Urban, J.F., Beckmann, M.P., Park, L.S., Schooley, K.A., Coffman, R.L., Mosmann, T.R., Paul, W.E. Annu. Rev. Immunol. (1990)
- IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Horsley, V., Jansen, K.M., Mills, S.T., Pavlath, G.K. Cell (2003)
- The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Kosarová, M., Havelková, H., Krulová, M., Demant, P., Lipoldová, M. Immunogenetics. (1999)
- Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Lipoldová, M., Svobodová, M., Krulová, M., Havelková, H., Badalová, J., Nohýnková, E., Holán, V., Hart, A.A., Volf, P., Demant, P. Genes. Immun. (2000)
- Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Kurey, I., Kobets, T., Havelková, H., Slapničková, M., Quan, L., Trtková, K., Grekov, I., Svobodová, M., Stassen, A.P., Hutson, A., Demant, P., Lipoldová, M. Immunogenetics. (2009)
- Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Havelková, H., Badalová, J., Svobodová, M., Vojtíková, J., Kurey, I., Vladimirov, V., Demant, P., Lipoldová, M. Genes. Immun. (2006)
- Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility. Lipoldová, M., Havelková, H., Badalová, J., Demant, P. Int. J. Cancer. (2005)
- Immunity to Trichinella spiralis infection in vitamin A-deficient mice. Carman, J.A., Pond, L., Nashold, F., Wassom, D.L., Hayes, C.E. J. Exp. Med. (1992)
- Development of murine allergic asthma is dependent upon B7-2 costimulation. Keane-Myers, A.M., Gause, W.C., Finkelman, F.D., Xhou, X.D., Wills-Karp, M. J. Immunol. (1998)
- Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Chuvpilo, S., Schomberg, C., Gerwig, R., Heinfling, A., Reeves, R., Grummt, F., Serfling, E. Nucleic Acids Res. (1993)
- Role of interleukin-4 (IL-4) and IL-10 in serum immunoglobulin G antibody responses following mucosal or systemic reovirus infection. Mathers, A.R., Cuff, C.F. J. Virol. (2004)
- Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice. Dieli, F., Sireci, G., Scirè, E., Salerno, A., Bellavia, A. Immunology (1999)
- Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells. Makar, K.W., Pérez-Melgosa, M., Shnyreva, M., Weaver, W.M., Fitzpatrick, D.R., Wilson, C.B. Nat. Immunol. (2003)
- EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. Koyanagi, M., Baguet, A., Martens, J., Margueron, R., Jenuwein, T., Bix, M. J. Biol. Chem. (2005)
- Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11. Wenderfer, S.E., Slack, J.P., McCluskey, T.S., Monaco, J.J. Genomics (2000)
- Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Ohara, J., Paul, W.E. Nature (1985)
- Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13. Guo, L., Hu-Li, J., Paul, W.E. Immunity (2005)
- Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Ansel, K.M., Greenwald, R.J., Agarwal, S., Bassing, C.H., Monticelli, S., Interlandi, J., Djuretic, I.M., Lee, D.U., Sharpe, A.H., Alt, F.W., Rao, A. Nat. Immunol. (2004)
- B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Brown, M.A., Pierce, J.H., Watson, C.J., Falco, J., Ihle, J.N., Paul, W.E. Cell (1987)
- Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Konishi, M., Azuma, C., Tominaga, A., Bergstedt-Lindqvist, S., Takahashi, M. Nature (1986)
- Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Kaplan, M.H., Schindler, U., Smiley, S.T., Grusby, M.J. Immunity (1996)
- Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Choi, M.S., Brines, R.D., Holman, M.J., Klaus, G.G. Immunity (1994)
- Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. Stein, M., Keshav, S., Harris, N., Gordon, S. J. Exp. Med. (1992)
- Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. Vella, A., Teague, T.K., Ihle, J., Kappler, J., Marrack, P. J. Exp. Med. (1997)
- Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma. Bradley, L.M., Duncan, D.D., Tonkonogy, S., Swain, S.L. J. Exp. Med. (1991)
- Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Herrick, C.A., MacLeod, H., Glusac, E., Tigelaar, R.E., Bottomly, K. J. Clin. Invest. (2000)
- Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. Ma, B., Blackburn, M.R., Lee, C.G., Homer, R.J., Liu, W., Flavell, R.A., Boyden, L., Lifton, R.P., Sun, C.X., Young, H.W., Elias, J.A. J. Clin. Invest. (2006)
- Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid, and multipotential progenitor cells. Rennick, D., Jackson, J., Yang, G., Wideman, J., Lee, F., Hudak, S. Blood (1989)
- JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes. Yin, T., Tsang, M.L., Yang, Y.C. J. Biol. Chem. (1994)
- Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins. Gold, M.R., Duronio, V., Saxena, S.P., Schrader, J.W., Aebersold, R. J. Biol. Chem. (1994)
- CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. Lu, P., Zhou, X., Chen, S.J., Moorman, M., Morris, S.C., Finkelman, F.D., Linsley, P., Urban, J.F., Gause, W.C. J. Exp. Med. (1994)
- Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. Naoe, Y., Setoguchi, R., Akiyama, K., Muroi, S., Kuroda, M., Hatam, F., Littman, D.R., Taniuchi, I. J. Exp. Med. (2007)
- Role of common cytokine receptor gamma chain (gamma(c))- and Jak3-dependent signaling in the proliferation and survival of murine mast cells. Suzuki, K., Nakajima, H., Watanabe, N., Kagami, S., Suto, A., Saito, Y., Saito, T., Iwamoto, I. Blood (2000)
- c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway. Ueno, H., Sasaki, K., Honda, H., Nakamoto, T., Yamagata, T., Miyagawa, K., Mitani, K., Yazaki, Y., Hirai, H. Blood (1998)
- IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. Wang, L.M., Keegan, A.D., Paul, W.E., Heidaran, M.A., Gutkind, J.S., Pierce, J.H. EMBO J. (1992)
- Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching. Mandler, R., Chu, C.C., Paul, W.E., Max, E.E., Snapper, C.M. J. Exp. Med. (1993)
- Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells. Jacobsen, S.E., Okkenhaug, C., Veiby, O.P., Caput, D., Ferrara, P., Minty, A. J. Exp. Med. (1994)
- IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells. Suzuki, K., Nakajima, H., Ikeda, K., Maezawa, Y., Suto, A., Takatori, H., Saito, Y., Iwamoto, I. J. Exp. Med. (2003)
- Interleukin 2 plays a central role in Th2 differentiation. Cote-Sierra, J., Foucras, G., Guo, L., Chiodetti, L., Young, H.A., Hu-Li, J., Zhu, J., Paul, W.E. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells. Rennick, D., Yang, G., Muller-Sieburg, C., Smith, C., Arai, N., Takabe, Y., Gemmell, L. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism. Dufort, F.J., Bleiman, B.F., Gumina, M.R., Blair, D., Wagner, D.J., Roberts, M.F., Abu-Amer, Y., Chiles, T.C. J. Immunol. (2007)
- Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Hodge, M.R., Ranger, A.M., Charles de la Brousse, F., Hoey, T., Grusby, M.J., Glimcher, L.H. Immunity (1996)
- IL-4-deficient Balb/c mice resist infection with Leishmania major. Kopf, M., Brombacher, F., Köhler, G., Kienzle, G., Widmann, K.H., Lefrang, K., Humborg, C., Ledermann, B., Solbach, W. J. Exp. Med. (1996)
- Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. Dallman, M.J., Larsen, C.P., Morris, P.J. J. Exp. Med. (1991)