Gene Review:
Socs3 - suppressor of cytokine signaling 3
Mus musculus
Synonyms:
CIS-3, CIS3, Cis3, Cish3, Cytokine-inducible SH2 protein 3, ...
Denson,
Held,
Menon,
Frank,
Parlow,
Arnold,
Fang,
Dai,
Yu,
Gong,
Dennis,
Jefferson,
Singh,
Ganapamo,
Philipp,
Boisclair,
Wang,
Shi,
Hurst,
Ooi,
Nicholson,
Willson,
Farley,
Starr,
Zhang,
Baca,
Alexander,
Metcalf,
Hilton,
Nicola,
Horiuchi,
Bae,
Katayama,
Oshikawa,
Okamoto,
Sato,
Haque,
Harbor,
Williams,
- Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Howard, J.K., Cave, B.J., Oksanen, L.J., Tzameli, I., Bjørbaek, C., Flier, J.S. Nat. Med. (2004)
- Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K.R., Yasukawa, H., Yoshimura, A. Nat. Med. (2004)
- Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. Boisclair, Y.R., Wang, J., Shi, J., Hurst, K.R., Ooi, G.T. J. Biol. Chem. (2000)
- Growth hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3. Wu, X., Herndon, D.N., Wolf, S.E. Shock (2003)
- Mycobacterium bovis bacillus Calmette-Guérin infection promotes SOCS induction and inhibits IFN-gamma-stimulated JAK/STAT signaling in J774 macrophages. Imai, K., Kurita-Ochiai, T., Ochiai, K. FEMS Immunol. Med. Microbiol. (2003)
- SOCS3 is essential in the regulation of fetal liver erythropoiesis. Marine, J.C., McKay, C., Wang, D., Topham, D.J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., Ihle, J.N. Cell (1999)
- Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki, K., Kondo, T., Kahn, C.R. Mol. Cell. Biol. (2004)
- Gene delivery of SOCS3 protects mice from lethal endotoxic shock. Fang, M., Dai, H., Yu, G., Gong, F. Cell. Mol. Immunol. (2005)
- SOCS3 regulates the plasticity of gp130 signaling. Lang, R., Pauleau, A.L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J.N., Rutschman, R., Murray, P.J. Nat. Immunol. (2003)
- Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin. Jegalian, A.G., Wu, H. J. Biol. Chem. (2002)
- Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Chen, Z., Laurence, A., Kanno, Y., Pacher-Zavisin, M., Zhu, B.M., Tato, C., Yoshimura, A., Hennighausen, L., O'Shea, J.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Bjørbaek, C., Elmquist, J.K., El-Haschimi, K., Kelly, J., Ahima, R.S., Hileman, S., Flier, J.S. Endocrinology (1999)
- Interferon-gamma produced by encephalitogenic cells induces suppressors of cytokine signaling in primary murine astrocytes. Stark, J.L., Lyons, J.A., Cross, A.H. J. Neuroimmunol. (2004)
- The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. Wormald, S., Zhang, J.G., Krebs, D.L., Mielke, L.A., Silver, J., Alexander, W.S., Speed, T.P., Nicola, N.A., Hilton, D.J. J. Biol. Chem. (2006)
- Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling. Haque, S.J., Harbor, P.C., Williams, B.R. J. Biol. Chem. (2000)
- Interleukin-10 Anti-Inflammatory Response to Borrelia burgdorferi, the Agent of Lyme Disease: a Possible Role for Suppressors of Cytokine Signaling 1 and 3. Dennis, V.A., Jefferson, A., Singh, S.R., Ganapamo, F., Philipp, M.T. Infect. Immun. (2006)
- SOCS-3 is an insulin-induced negative regulator of insulin signaling. Emanuelli, B., Peraldi, P., Filloux, C., Sawka-Verhelle, D., Hilton, D., Van Obberghen, E. J. Biol. Chem. (2000)
- Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. Takatori, H., Nakajima, H., Kagami, S., Hirose, K., Suto, A., Suzuki, K., Kubo, M., Yoshimura, A., Saito, Y., Iwamoto, I. J. Immunol. (2005)
- Analysis of SOCS-3 promoter responses to interferon gamma. Gatto, L., Berlato, C., Poli, V., Tininini, S., Kinjyo, I., Yoshimura, A., Cassatella, M.A., Bazzoni, F. J. Biol. Chem. (2004)
- BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. Liu, Y., Dong, W., Chen, L., Xiang, R., Xiao, H., De, G., Wang, Z., Qi, Y. J. Biol. Chem. (2004)
- SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. Emanuelli, B., Peraldi, P., Filloux, C., Chavey, C., Freidinger, K., Hilton, D.J., Hotamisligil, G.S., Van Obberghen, E. J. Biol. Chem. (2001)
- SOCS3 negatively regulates IL-6 signaling in vivo. Croker, B.A., Krebs, D.L., Zhang, J.G., Wormald, S., Willson, T.A., Stanley, E.G., Robb, L., Greenhalgh, C.J., Förster, I., Clausen, B.E., Nicola, N.A., Metcalf, D., Hilton, D.J., Roberts, A.W., Alexander, W.S. Nat. Immunol. (2003)
- Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. Nicholson, S.E., Willson, T.A., Farley, A., Starr, R., Zhang, J.G., Baca, M., Alexander, W.S., Metcalf, D., Hilton, D.J., Nicola, N.A. EMBO J. (1999)
- Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3. Denson, L.A., Held, M.A., Menon, R.K., Frank, S.J., Parlow, A.F., Arnold, D.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Lipoteichoic acid-related molecule derived from the streptococcal preparation, OK-432, which suppresses atopic dermatitis-like lesions in NC/Nga mice. Horiuchi, Y., Bae, S., Katayama, I., Oshikawa, T., Okamoto, M., Sato, M. Arch. Dermatol. Res. (2006)
- A novel role for suppressor of cytokine signaling 3 in cartilage destruction via induction of chondrocyte desensitization toward insulin-like growth factor. Smeets, R.L., Veenbergen, S., Arntz, O.J., Bennink, M.B., Joosten, L.A., van den Berg, W.B., van de Loo, F.A. Arthritis Rheum. (2006)
- Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion. Auernhammer, C.J., Chesnokova, V., Bousquet, C., Melmed, S. Mol. Endocrinol. (1998)
- Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Li, Y., McClintick, J., Zhong, L., Edenberg, H.J., Yoder, M.C., Chan, R.J. Blood (2005)