Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Cgp-40215A 3-[(E)-[[N'-[(3- carbamimidoylphenyl)methyl...

Synonyms:

Bacchi, C.J. et al., Nguyen, B. et al.

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High impact information on Cgp-40215A

MGBG has modest activity as an inhibitor of trypanosome S-adenosylmethionine decarboxylase (50% inhibitory concentration [IC50]. 130 microM), while CGP 40215A was a more active inhibitor (IC50, 20 microM) [1].

Analytical, diagnostic and therapeutic context of Cgp-40215A

Spectrophotometric titrations of CGP 40215A binding to poly(dAT)(2) have characteristics of DNA-binding-induced spectral changes as well as effects due to binding-induced protonation of the compound linker [2].

References

In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Bacchi, C.J., Brun, R., Croft, S.L., Alicea, K., Bühler, Y. Antimicrob. Agents Chemother. (1996) [Pubmed]
Characterization of a novel DNA minor-groove complex. Nguyen, B., Hamelberg, D., Bailly, C., Colson, P., Stanek, J., Brun, R., Neidle, S., Wilson, W.D. Biophys. J. (2004) [Pubmed]

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