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Gene Review

Amd1  -  S-adenosylmethionine decarboxylase 1

Mus musculus

Synonyms: AdoMetDC, AdoMetDC 1, Amd-1, S-adenosylmethionine decarboxylase proenzyme 1, SAMDC, ...
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Disease relevance of Amd1


High impact information on Amd1


Chemical compound and disease context of Amd1


Biological context of Amd1

  • Homozygous (Amd1(-/-)) blastocysts at E3.5 arrested cell proliferation immediately after the onset of cell culture, and this arrest was rescued by the addition of spermidine [12].
  • However, homozygous Amd1(-/-) embryos died early in embryonic development, between E3.5 and E6.5 days post-coitus [12].
  • RESULTS: Our study demonstrated that adenovirus-mediated ODC and AdoMetDC antisense expression inhibits tumor cell growth through a blockade of the polyamine synthesis pathway [1].
  • We have previously identified a mouse AdoMetDC gene that exhibits the hallmarks of a retroposon; that is, it has no introns, is flanked by direct repeats, and has a poly(dA) tract at its 3'-end [13].
  • These results were confirmed by transfecting these cells with plasmids containing a luciferase complementary DNA fused to follow the 5'UTR from ODC or AdoMetDC [14].

Anatomical context of Amd1


Associations of Amd1 with chemical compounds


Regulatory relationships of Amd1


Other interactions of Amd1

  • The level of ODC activity is about 70 fold higher at the time of birth than in the adult mouse, whereas AdoMetDC activity is very low after birth and increases as the brain matures [22].
  • Drug-induced elevations in ODC and, to a lesser extent, AdoMetDC activities were reversed by later treatment with exogenous AdoMet [23].
  • In these cultures, AdoMetDC activity decreased with a t1/2 of 7 h during transition from long slender to short stumpy-like forms as soon as the stationary phase was reached [24].
  • The alphaMHC (alpha-myosin heavy chain) promoter was used to generate transgenic mice with cardiac-specific expression of AdoMetDC [11].
  • Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717 [25].

Analytical, diagnostic and therapeutic context of Amd1


  1. Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. Zhang, B., Liu, X.X., Zhang, Y., Jiang, C.Y., Hu, H.Y., Gong, L., Liu, M., Teng, Q.S. The journal of gene medicine. (2006) [Pubmed]
  2. Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo. Hu, X., Washington, S., Verderame, M.F., Demers, L.M., Mauger, D., Manni, A. Int. J. Oncol. (2004) [Pubmed]
  3. Growth factor-mediated altered expression and regulation of S-adenosylmethionine decarboxylase in a H-ras transformed cell line capable of malignant progression. Hardin, M.S., Hurta, R.A. J. Cell. Biochem. (2002) [Pubmed]
  4. Effects of treatments with alpha-difluoromethylornithine and hyperthermia on the growth and polyamine metabolism of Harding-Passey murine melanoma. Lopez Ballester, J.A., Peñafiel, R., Cremades, A., Valcarcel, M.M., Solano, F., Lozano, J.A. Anticancer Res. (1991) [Pubmed]
  5. Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane. Igarashi, K., Koga, K., He, Y., Shimogori, T., Ekimoto, H., Kashiwagi, K., Shirahata, A. Cancer Res. (1995) [Pubmed]
  6. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Regenass, U., Mett, H., Stanek, J., Mueller, M., Kramer, D., Porter, C.W. Cancer Res. (1994) [Pubmed]
  7. Polyamines in testosterone-induced hypertrophic and antifolate-induced hyperplastic mouse kidney. Differential effect of alpha-difluoromethylornithine. Manteuffel-Cymborowska, M., Chmurzyńska, W., Grzelakowska-Sztabert, B. Biochim. Biophys. Acta (1993) [Pubmed]
  8. Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells. Käpyaho, K., Sinervirta, R., Jänne, J. Cancer Res. (1985) [Pubmed]
  9. Polyamine biosynthesis enzymes in the induction and inhibition of differentiation in Friend erythroleukemia cells. Gazitt, Y., Friend, C. Cancer Res. (1980) [Pubmed]
  10. Combined use of alpha-difluoromethylornithine and an inhibitor of S-adenosylmethionine decarboxylase in mice bearing P388 leukemia or Lewis lung carcinoma. Nakaike, S., Kashiwagi, K., Terao, K., Iio, K., Igarashi, K. Jpn. J. Cancer Res. (1988) [Pubmed]
  11. Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. Nisenberg, O., Pegg, A.E., Welsh, P.A., Keefer, K., Shantz, L.M. Biochem. J. (2006) [Pubmed]
  12. Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Nishimura, K., Nakatsu, F., Kashiwagi, K., Ohno, H., Saito, T., Igarashi, K. Genes Cells (2002) [Pubmed]
  13. The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene (Odc) on chromosome 12 and is present in distantly related species of the genus Mus. Persson, K., Heby, O., Berger, F.G. Mamm. Genome (1999) [Pubmed]
  14. Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. Shantz, L.M., Pegg, A.E. Cancer Res. (1994) [Pubmed]
  15. Altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression and regulation in mouse fibroblasts transformed with oncogenes or constitutively active Mitogen-Activated Protein (MAP) kinase kinase. Hurta, R.A. Mol. Cell. Biochem. (2000) [Pubmed]
  16. Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene. Halmekytö, M., Alhonen, L., Wahlfors, J., Sinervirta, R., Eloranta, T., Jänne, J. Biochem. J. (1991) [Pubmed]
  17. Induction of ornithine decarboxylase activity in mouse tissues by phorbol ester is effectively blocked by methylglyoxal bis(butylamidinohydrazone). Hibasami, H., Tsukada, T., Maekawa, S., Sakurai, M., Nakashima, K. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  18. Overproduction of S-adenosylmethionine decarboxylase in ethylglyoxal-bis(guanylhydrazone)-resistant mouse FM3A cells. Suzuki, T., Sadakata, Y., Kashiwagi, K., Hoshino, K., Kakinuma, Y., Shirahata, A., Igarashi, K. Eur. J. Biochem. (1993) [Pubmed]
  19. Tumour promoter mediated altered expression and regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in H-ras-transformed fibrosarcoma cell lines. Voskas, D., Mader, R., Lee, J., Hurta, R.A. Biochem. Cell Biol. (2001) [Pubmed]
  20. Altered polyamine metabolism in the PRO/Re strain of inbred mice. Manen, C.A., Blake, R.L., Russell, D.H. Biochem. J. (1976) [Pubmed]
  21. S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression. Hurta, R.A. J. Cell. Biochem. Suppl. (2001) [Pubmed]
  22. Developmental expression of ornithine and S-adenosylmethionine decarboxylases in mouse brain. Suorsa, A., Hietala, O., Pajunen, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  23. Modulation of polyamine-biosynthetic activity by S-adenosylmethionine depletion. Kramer, D.L., Sufrin, J.R., Porter, C.W. Biochem. J. (1988) [Pubmed]
  24. Down regulation of S-adenosyl-L-methionine decarboxylase activity of Trypanosoma brucei during transition from long slender to short stumpy-like forms in axenic culture. Selzer, P.M., Hesse, F., Hamm-Kunzelmann, B., Muhlstadt, K., Echner, H., Duszenko, M. Eur. J. Cell Biol. (1996) [Pubmed]
  25. Up-regulation of spermidine/spermine N1-acetyltransferase (SSAT) expression is a part of proliferative but not anabolic response of mouse kidney. Dudkowska, M., Stachurska, A., Grzelakowska-Sztabert, B., Manteuffel-Cymborowska, M. Acta Biochim. Pol. (2002) [Pubmed]
  26. Stabilization of ornithine decarboxylase in mouse liver and lung by methylglyoxal bis(cyclohexylamidinohydrazone). Hibasami, H., Maekawa, S., Murata, T., Nakashima, K. Biochem. Pharmacol. (1988) [Pubmed]
  27. Molecular cloning of the mouse S-adenosylmethionine decarboxylase cDNA: specific protein binding to the conserved region of the mRNA 5'-untranslated region. Waris, T., Ihalainen, R., Keränen, M.R., Pajunen, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  28. The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine. Dependence of ornithine decarboxylase induction on beta-adrenoceptors. Hietala, O.A., Laitinen, S.I., Laitinen, P.H., Lapinjoki, S.P., Pajunen, A.E. Biochem. Pharmacol. (1983) [Pubmed]
  29. S-adenosylmethionine decarboxylase as target of chemotherapy. Jänne, J., Alhonen-Hongisto, L., Nikula, P., Elo, H. Adv. Enzyme Regul. (1985) [Pubmed]
  30. Localization of S-adenosylmethionine decarboxylase in murine tissues by immunohistochemistry. Gritli-Linde, A., Holm, I., Linde, A. Eur. J. Oral Sci. (1995) [Pubmed]
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