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Chemical Compound Review:

Herbicolin A N-[(E)-1-[[12-(2- aminocarbonylethyl)-3-[3...

Synonyms: AC1O5Q7M, 74188-23-1

Birkelund, S. et al., Mittenbühler, K. et al., Greiner, M. et al., Freundt, E.A. et al., Tenning, P. et al.

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Disease relevance of Herbicolin A

Activity of herbicolin A against Mycoplasma, Acholeplasma, Ureaplasma, and Spiroplasma species [1].
Electron microscopy of negatively stained mycoplasma, ureaplasma, and acholeplasma cells showed ultrastructural changes after 10 min of treatment of the organisms with the peptide antibiotic herbicolin A in concentrations ranging from 10 micrograms/ml for Mycoplasma capricolum to 600 micrograms/ml for Ureaplasma urealyticum [2].
Ultrastructural changes in mollicutes induced by the peptide antibiotic herbicolin A [2].
Erwinia herbicola CHS1065 produces antifungal compounds highly related to herbicolin A [3].

High impact information on Herbicolin A

A marked enhancement of the humoral immune response was obtained with the low molecular mass antigens Iturin AL, Herbicolin A and Microcystin (MLR) coupled to poly-l-lysin (MLR-PLL), in rabbits and in chickens [4].

Analytical, diagnostic and therapeutic context of Herbicolin A

Rapid identification and determination of herbicolin A and B by high-performance liquid chromatography [5].

References

Activity of herbicolin A against Mycoplasma, Acholeplasma, Ureaplasma, and Spiroplasma species. Freundt, E.A., Winkelmann, G. Antimicrob. Agents Chemother. (1984) [Pubmed]
Ultrastructural changes in mollicutes induced by the peptide antibiotic herbicolin A. Birkelund, S., Freundt, E.A., Christiansen, G. Antimicrob. Agents Chemother. (1986) [Pubmed]
Cloning and transfer of genes for antifungal compounds from Erwinia herbicola to Escherichia coli. Tenning, P., Van Rijsbergen, R., Zhao, Y., Joos, H. Mol. Plant Microbe Interact. (1993) [Pubmed]
Drug specific antibodies: T-cell epitope-lipopeptide conjugates are potent adjuvants for small antigens in vivo and in vitro. Mittenbühler, K., Loleit, M., Baier, W., Fischer, B., Sedelmeier, E., Jung, G., Winkelmann, G., Jacobi, C., Weckesser, J., Erhard, M.H., Hofmann, A., Bessler, W., Hoffmann, P. Int. J. Immunopharmacol. (1997) [Pubmed]
Rapid identification and determination of herbicolin A and B by high-performance liquid chromatography. Greiner, M., Winkelmann, G. J. Chromatogr. (1990) [Pubmed]

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