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Disease relevance of Ureaplasma


High impact information on Ureaplasma


Chemical compound and disease context of Ureaplasma


Biological context of Ureaplasma


Anatomical context of Ureaplasma


Gene context of Ureaplasma

  • Among symptomatic women, the likelihood ratio (LR+) for the prediction of PTD was found to be greater than 10 using amniotic fluid (AF) interleukin-6 (IL-6), AF Ureaplasma urealyticum, as well as a multi-marker consisting of cervical IL-6, cervical IL-8, and cervical length (CL) [26].
  • The inflammatory response to the presence of Ureaplasma urealyticum or Mycoplasma hominis in the lower genital tract of subfertile men without any signs or symptoms of infection was investigated by measuring the concentrations of interleukin (IL)-6, IL-8, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in seminal plasma [27].
  • OBJECTIVE: To determine whether Ureaplasma urealyticum respiratory tract colonization in very low birth weight infants during the first week of life is associated with changes in tracheal aspirate concentrations of the cytokines interleukin 1-beta (IL-1-beta), tumor necrosis factor alpha (TNF-alpha) and IL-6 [28].
  • Ureaplasma urealyticum strains of all serotypes express a specific human immunoglobulin A1 protease that cleaves immunoglobulin A1 to produce intact Fab and Fc fragments [29].
  • Small repeating units within the Ureaplasma urealyticum MB antigen gene encode serovar specificity and are associated with antigen size variation [30].

Analytical, diagnostic and therapeutic context of Ureaplasma


  1. Ureaplasma urealyticum and Mycoplasma hominis in women with systemic lupus erythematosus. Ginsburg, K.S., Kundsin, R.B., Walter, C.W., Schur, P.H. Arthritis Rheum. (1992) [Pubmed]
  2. Role of erythromycin for treatment of incipient chronic lung disease in preterm infants colonised with Ureaplasma urealyticum. Bührer, C., Hoehn, T., Hentschel, J. Drugs (2001) [Pubmed]
  3. Effect of reducing agents, catalase, and reuse of medium on toxicity of media for growth of Ureaplasma urealyticum. Sayed, I.A., Kenny, G.E. J. Infect. Dis. (1979) [Pubmed]
  4. Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery. Gerber, S., Vial, Y., Hohlfeld, P., Witkin, S.S. J. Infect. Dis. (2003) [Pubmed]
  5. Roxithromycin in nongonococcal urethritis. Lassus, A., Seppala, A. J. Antimicrob. Chemother. (1987) [Pubmed]
  6. Structures of thymidine kinase 1 of human and mycoplasmic origin. Welin, M., Kosinska, U., Mikkelsen, N.E., Carnrot, C., Zhu, C., Wang, L., Eriksson, S., Munch-Petersen, B., Eklund, H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Ureaplasma urealyticum urease genes; use of a UGA tryptophan codon. Blanchard, A. Mol. Microbiol. (1990) [Pubmed]
  8. Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas. Waites, K.B., Reddy, N.B., Crabb, D.M., Duffy, L.B. Antimicrob. Agents Chemother. (2005) [Pubmed]
  9. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Waites, K.B., Crabb, D.M., Bing, X., Duffy, L.B. Antimicrob. Agents Chemother. (2003) [Pubmed]
  10. In vitro activities of ABT-773 and other antimicrobials against human mycoplasmas. Waites, K.B., Crabb, D.M., Duffy, L.B. Antimicrob. Agents Chemother. (2003) [Pubmed]
  11. Dissemination of the tetM tetracycline resistance determinant to Ureaplasma urealyticum. Roberts, M.C., Kenny, G.E. Antimicrob. Agents Chemother. (1986) [Pubmed]
  12. Susceptibilities of neonatal respiratory isolates of Ureaplasma urealyticum to antimicrobial agents. Matlow, A., Th'ng, C., Kovach, D., Quinn, P., Dunn, M., Wang, E. Antimicrob. Agents Chemother. (1998) [Pubmed]
  13. Growth inhibition of Ureaplasma urealyticum by the proton pump inhibitor lansoprazole: direct attribution to inhibition by lansoprazole of urease activity and urea-induced ATP synthesis in U. urealyticum. Nagata, K., Takagi, E., Satoh, H., Okamura, H., Tamura, T. Antimicrob. Agents Chemother. (1995) [Pubmed]
  14. Susceptibilities of Mycoplasma hominis and Ureaplasma urealyticum to two new quinolones, sparfloxacin and WIN 57273. Kenny, G.E., Cartwright, F.D. Antimicrob. Agents Chemother. (1991) [Pubmed]
  15. Minocycline resistance among clinical isolates of Ureaplasma urealyticum. Magalhães, M., Veras, A. J. Infect. Dis. (1984) [Pubmed]
  16. Cloning and characterization of tetM gene from a Ureaplasma urealyticum strain. Brown, J.T., Roberts, M.C. Antimicrob. Agents Chemother. (1987) [Pubmed]
  17. The static effect of rosaramicin on Ureaplasma urealyticum and the development of antibiotic resistance. Taylor-Robinson, D., Furr, P.M. J. Antimicrob. Chemother. (1982) [Pubmed]
  18. Susceptibility of mycoplasmas to antimicrobial agents: clinical implications. McCormack, W.M. Clin. Infect. Dis. (1993) [Pubmed]
  19. Frequency and significance of isolation of Ureaplasma urealyticum and Mycoplasma hominis from cerebrospinal fluid and tracheal aspirate specimens from low birth weight infants. Heggie, A.D., Jacobs, M.R., Butler, V.T., Baley, J.E., Boxerbaum, B. J. Pediatr. (1994) [Pubmed]
  20. Microbiology of specimens obtained by laparoscopy from controls and from patients with pelvic inflammatory disease or infertility with tubal obstruction: Chlamydia trachomatis and Ureaplasma urealyticum. Henry-Suchet, J., Catalan, F., Loffredo, V., Serfaty, D., Siboulet, A., Perol, Y., Sanson, M.J., Debache, C., Pigeau, F., Coppin, R., de Brux, J., Poynard, T. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  21. Ureaplasma urealyticum and infertility: the effect of different antibiotic regimens on the semen quality. Toth, A., Lesser, M.L. J. Urol. (1982) [Pubmed]
  22. Enhancement of Ureaplasma urealyticum growth on a differential agar medium (A7B) by a polyamine, putrescine. Shepard, M.C., Combs, R.S. J. Clin. Microbiol. (1979) [Pubmed]
  23. Mycoplasma-mediated uptake of the exogenous human BRCA1 gene by hatching blastocysts. Chan, P.J., Brossfield, J.E., Patton, W.C., King, A. J. Assist. Reprod. Genet. (1999) [Pubmed]
  24. Inhibition of macrophage proinflammatory cytokine expression by steroids and recombinant IL-10. Li, Y.H., Brauner, A., Jonsson, B., Van der Ploeg, I., Söder, O., Holst, M., Jensen, J.S., Lagercrantz, H., Tullus, K. Biol. Neonate (2001) [Pubmed]
  25. Morphological lesions of the rat urinary tract induced by inoculation of mycoplasmas and other urinary tract pathogens. Larsson, P.A., Cano, M., Grenabo, L., Brorson, J.E., Hedelin, H., Pettersson, S., Johansson, S.L. Urologia internationalis. (1989) [Pubmed]
  26. Biomarkers for the prediction of preterm delivery. Vogel, I., Thorsen, P., Curry, A., Sandager, P., Uldbjerg, N. Acta obstetricia et gynecologica Scandinavica. (2005) [Pubmed]
  27. Cytokine concentrations in seminal plasma from subfertile men are not indicative of the presence of Ureaplasma urealyticum or Mycoplasma hominis in the lower genital tract. Pannekoek, Y., Trum, J.W., Bleker, O.P., van der Veen, F., Spanjaard, L., Dankert, J. J. Med. Microbiol. (2000) [Pubmed]
  28. Ureaplasma urealyticum respiratory tract colonization is associated with an increase in interleukin 1-beta and tumor necrosis factor alpha relative to interleukin 6 in tracheal aspirates of preterm infants. Patterson, A.M., Taciak, V., Lovchik, J., Fox, R.E., Campbell, A.B., Viscardi, R.M. Pediatr. Infect. Dis. J. (1998) [Pubmed]
  29. Characterization of the immunoglobulin A protease of Ureaplasma urealyticum. Spooner, R.K., Russell, W.C., Thirkell, D. Infect. Immun. (1992) [Pubmed]
  30. Small repeating units within the Ureaplasma urealyticum MB antigen gene encode serovar specificity and are associated with antigen size variation. Zheng, X., Teng, L.J., Watson, H.L., Glass, J.I., Blanchard, A., Cassell, G.H. Infect. Immun. (1995) [Pubmed]
  31. High-density lipoprotein that supports Ureaplasma urealyticum growth. Sayed, I.A., Sweat, F.W. J. Bacteriol. (1982) [Pubmed]
  32. Ureaplasma urealyticum-induced crystallization of magnesium ammonium phosphate and calcium phosphates in synthetic urine. Grenabo, L., Brorson, J.E., Hedelin, H., Pettersson, S. J. Urol. (1984) [Pubmed]
  33. Bacterial 16S rDNA polymerase chain reaction in the detection of intra-amniotic infection. Jalava, J., Mäntymaa, M.L., Ekblad, U., Toivanen, P., Skurnik, M., Lassila, O., Alanen, A. British journal of obstetrics and gynaecology. (1996) [Pubmed]
  34. Serum concentrations of erythromycin after intravenous infusion in preterm neonates treated for Ureaplasma urealyticum infection. Waites, K.B., Sims, P.J., Crouse, D.T., Geerts, M.H., Shoup, R.E., Hamrick, W.B., Duffy, L.B., Cassell, G.H. Pediatr. Infect. Dis. J. (1994) [Pubmed]
  35. Investigation into the inhibitory effect of flurofamide on animal ureaplasmas and its use in the treatment of ureaplasma-infected sheep. Ball, H.J., McCaughey, W.J. J. Vet. Pharmacol. Ther. (1986) [Pubmed]
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