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MeSH Review


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Disease relevance of Mycoplasma


High impact information on Mycoplasma


Chemical compound and disease context of Mycoplasma


Biological context of Mycoplasma


Anatomical context of Mycoplasma


Gene context of Mycoplasma

  • Heat-inactivated mycoplasma particles induce inflammatory cytokines such as IL-1, IL-6, and TNF in monocytes, as well as in THP-1 cells [26].
  • Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions [27].
  • We evaluated the effects of mycoplasma infection on the steady-state mRNA levels of two cytokines IL-1 alpha and beta [28].
  • TLR6 has been shown to be required for the recognition of diacylated lipoproteins and lipopeptides derived from mycoplasma and to activate the NF-kappaB signaling cascade in conjunction with TLR2 [29].
  • A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways [30].

Analytical, diagnostic and therapeutic context of Mycoplasma


  1. Lack of activity of zidovudine against Ureaplasma urealyticum and Mycoplasma hominis. Madoff, S., Ferraro, M.J., Merrill, D.P., Hirsch, M.S. Lancet (1992) [Pubmed]
  2. Chlamydiae and mycoplasma genital infection in salpingitis and tubal sterility. Henry-Suchet, J., Loffredo, V. Lancet (1980) [Pubmed]
  3. Infection of human T cells with mycoplasma, inhibition of CD4 expression and HIV-1 gp120 glycoprotein binding, and infectivity. O'Toole, C., Lowdell, M. Lancet (1990) [Pubmed]
  4. Adenine formation from adenosine by mycoplasmas: adenosine phosphorylase activity. Hatanaka, M., Del Giudice, R., Long, C. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  5. An evolutionary conserved mechanism of T cell activation by microbial toxins. Evidence for different affinities of T cell receptor-toxin interaction. Fleischer, B., Gerardy-Schahn, R., Metzroth, B., Carrel, S., Gerlach, D., Köhler, W. J. Immunol. (1991) [Pubmed]
  6. Appearance of hypoxanthine guanine phosphoribosyltransferase activity as a consequence of mycoplasma contamination. Stanbridge, E.J., Tischfield, J.A., Schneider, E.L. Nature (1975) [Pubmed]
  7. Inflammatory toxin from Mycoplasma bovis: isolation and characterization. Geary, S.J., Tourtellotte, M.E., Cameron, J.A. Science (1981) [Pubmed]
  8. Inappropriate use of oral ciprofloxacin. Frieden, T.R., Mangi, R.J. JAMA (1990) [Pubmed]
  9. Mycoplasma superantigen is a CDR3-dependent ligand for the T cell antigen receptor. Hodtsev, A.S., Choi, Y., Spanopoulou, E., Posnett, D.N. J. Exp. Med. (1998) [Pubmed]
  10. Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. Mühlradt, P.F., Kiess, M., Meyer, H., Süssmuth, R., Jung, G. J. Exp. Med. (1997) [Pubmed]
  11. Dependency of sister chromatid exchange in T- and B-cells on the incorporation of deoxyribonucleosides into chromosomal DNA. Shiraishi, Y., Weinfeld, H., Minowada, J., Sandberg, A.A. J. Natl. Cancer Inst. (1976) [Pubmed]
  12. In-vitro activity of zidovudine against Mycoplasma. Taylor-Robinson, D., Furr, P.M. Lancet (1992) [Pubmed]
  13. A mycoplasma high-affinity transport system and the in vitro invasiveness of mouse sarcoma cells. Dudler, R., Schmidhauser, C., Parish, R.W., Wettenhall, R.E., Schmidt, T. EMBO J. (1988) [Pubmed]
  14. Filamentous structures in adherent Mycoplasma pneumoniae cells treated with nonionic detergents. Göbel, U., Speth, V., Bredt, W. J. Cell Biol. (1981) [Pubmed]
  15. Neurological disease associated with Mycoplasma pneumoniae pneumonitis: demonstration of viable Mycoplasma pneumoniae in cerebrospinal fluid and blood by radioisotopic and immunofluorescent tissue culture techniques. Bayer, A.S., Galpin, J.E., Theofilopoulos, A.N., Guze, L.B. Ann. Intern. Med. (1981) [Pubmed]
  16. Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes. Su, Z., Goldstein, N.I., Fisher, P.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Properties of a transfer RNA lacking modified nucleosides. Samuelsson, T., Borén, T., Johansen, T.I., Lustig, F. J. Biol. Chem. (1988) [Pubmed]
  18. Kinetics of cholesterol and phospholipid exchange between Mycoplasma gallisepticum cells and lipid vesicles. Alterations in membrane cholesterol and protein content. Clejan, S., Bittman, R. J. Biol. Chem. (1984) [Pubmed]
  19. Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors. Smith, D.W., Ganaway, R.L., Fahrney, D.E. J. Biol. Chem. (1978) [Pubmed]
  20. Signal transduction pathways involved in the activation of NF-kappa B, AP-1, and c-fos by Mycoplasma fermentans membrane lipoproteins in macrophages. Rawadi, G., Garcia, J., Lemercier, B., Roman-Roman, S. J. Immunol. (1999) [Pubmed]
  21. Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells. Friedman, S.M., Crow, M.K., Tumang, J.R., Tumang, M., Xu, Y.Q., Hodtsev, A.S., Cole, B.C., Posnett, D.N. J. Exp. Med. (1991) [Pubmed]
  22. Switching tRNA(Gln) identity from glutamine to tryptophan. Rogers, M.J., Adachi, T., Inokuchi, H., Söll, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  23. Effects of mycoplasma contamination on phenotypic expression of mitochondrial mutants in human cells. Doersen, C.J., Stanbridge, E.J. Mol. Cell. Biol. (1981) [Pubmed]
  24. Distribution and movement of sterols with different side chain structures between the two leaflets of the membrane bilayer of mycoplasma cells. Clejan, S., Bittman, R. J. Biol. Chem. (1984) [Pubmed]
  25. The N-terminal lipopeptide of a 44-kDa membrane-bound lipoprotein of Mycoplasma salivarium is responsible for the expression of intercellular adhesion molecule-1 on the cell surface of normal human gingival fibroblasts. Shibata, K., Hasebe, A., Into, T., Yamada, M., Watanabe, T. J. Immunol. (2000) [Pubmed]
  26. Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and cytocidal potential. Rawadi, G., Roman-Roman, S., Castedo, M., Dutilleul, V., Susin, S., Marchetti, P., Geuskens, M., Kroemer, G. J. Immunol. (1996) [Pubmed]
  27. Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions. Nishiguchi, M., Matsumoto, M., Takao, T., Hoshino, M., Shimonishi, Y., Tsuji, S., Begum, N.A., Takeuchi, O., Akira, S., Toyoshima, K., Seya, T. J. Immunol. (2001) [Pubmed]
  28. Differential effects of in vitro mycoplasma infection on interleukin-1 alpha and beta mRNA expression in U937 and A431 cells. Demczuk, S., Baumberger, C., Mach, B., Dayer, J.M. J. Biol. Chem. (1988) [Pubmed]
  29. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. Nakao, Y., Funami, K., Kikkawa, S., Taniguchi, M., Nishiguchi, M., Fukumori, Y., Seya, T., Matsumoto, M. J. Immunol. (2005) [Pubmed]
  30. A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways. Garcia, J., Lemercier, B., Roman-Roman, S., Rawadi, G. J. Biol. Chem. (1998) [Pubmed]
  31. Host discrimination of Mycoplasma pneumoniae proteinaceous immunogens. Leith, D.K., Trevino, L.B., Tully, J.G., Senterfit, L.B., Baseman, J.B. J. Exp. Med. (1983) [Pubmed]
  32. Triggering and exacerbation of autoimmune arthritis by the Mycoplasma arthritidis superantigen MAM. Cole, B.C., Griffiths, M.M. Arthritis Rheum. (1993) [Pubmed]
  33. Induction of chemokine gene expression by major histocompatibility complex class II ligands in human fibroblast-like synoviocytes. Differential regulation by interleukin-4 and dexamethasone. Mehindate, K., al-Daccak, R., Schall, T.J., Mourad, W. J. Biol. Chem. (1994) [Pubmed]
  34. In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Chen, T.R. Exp. Cell Res. (1977) [Pubmed]
  35. Detection of immunoglobulin G antibodies to cholesterol in antisera to mycoplasmas. Watanabe, T., Kumazawa, T. Infect. Immun. (1991) [Pubmed]
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