Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O5QO8 3-[(2Z,6Z,10Z,14Z,18Z)- 3,7,11,15,19,23...

Synonyms: 65848-03-5

Gin, P. et al., Do, T.Q. et al.

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High impact information on 3-Hexaprenyl-4-hydroxybenzoic acid

Here we have isolated the COQ6 gene by functional complementation and, in contrast to a previous report, find it is not an essential gene. coq6 mutants are unable to grow on nonfermentable carbon sources and do not synthesize Q but instead accumulate the Q biosynthetic intermediate 3-hexaprenyl-4-hydroxybenzoic acid [1].
Studies presented here indicate that abc1/coq8 null mutants are defective in Q biosynthesis and accumulate 3-hexaprenyl-4-hydroxybenzoic acid as the predominant intermediate [2].

References

The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. Gin, P., Hsu, A.Y., Rothman, S.C., Jonassen, T., Lee, P.T., Tzagoloff, A., Clarke, C.F. J. Biol. Chem. (2003) [Pubmed]
A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants. Do, T.Q., Hsu, A.Y., Jonassen, T., Lee, P.T., Clarke, C.F. J. Biol. Chem. (2001) [Pubmed]

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