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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Genes, Essential

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  1. An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. Soma, A., Ikeuchi, Y., Kanemasa, S., Kobayashi, K., Ogasawara, N., Ote, T., Kato, J., Watanabe, K., Sekine, Y., Suzuki, T. Mol. Cell (2003) [Pubmed]
  2. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Koshiji, M., To, K.K., Hammer, S., Kumamoto, K., Harris, A.L., Modrich, P., Huang, L.E. Mol. Cell (2005) [Pubmed]
  3. Characterization of the galU gene of Streptococcus pneumoniae encoding a uridine diphosphoglucose pyrophosphorylase: a gene essential for capsular polysaccharide biosynthesis. Mollerach, M., López, R., García, E. J. Exp. Med. (1998) [Pubmed]
  4. Pilin expression in Neisseria gonorrhoeae is under both positive and negative transcriptional control. Taha, M.K., So, M., Seifert, H.S., Billyard, E., Marchal, C. EMBO J. (1988) [Pubmed]
  5. ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. Abderrahmani, A., Cheviet, S., Ferdaoussi, M., Coppola, T., Waeber, G., Regazzi, R. EMBO J. (2006) [Pubmed]
  6. Strain-dependent alterations in the expression of folate pathway genes following teratogenic exposure to valproic acid in a mouse model. Finnell, R.H., Wlodarczyk, B.C., Craig, J.C., Piedrahita, J.A., Bennett, G.D. Am. J. Med. Genet. (1997) [Pubmed]
  7. The synthetic genetic interaction spectrum of essential genes. Davierwala, A.P., Haynes, J., Li, Z., Brost, R.L., Robinson, M.D., Yu, L., Mnaimneh, S., Ding, H., Zhu, H., Chen, Y., Cheng, X., Brown, G.W., Boone, C., Andrews, B.J., Hughes, T.R. Nat. Genet. (2005) [Pubmed]
  8. Perp is a p63-regulated gene essential for epithelial integrity. Ihrie, R.A., Marques, M.R., Nguyen, B.T., Horner, J.S., Papazoglu, C., Bronson, R.T., Mills, A.A., Attardi, L.D. Cell (2005) [Pubmed]
  9. painless, a Drosophila gene essential for nociception. Tracey, W.D., Wilson, R.I., Laurent, G., Benzer, S. Cell (2003) [Pubmed]
  10. Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA. Itzhaki, J.E., Gilbert, C.S., Porter, A.C. Nat. Genet. (1997) [Pubmed]
  11. A gene essential for de novo methylation and development in Ascobolus reveals a novel type of eukaryotic DNA methyltransferase structure. Malagnac, F., Wendel, B., Goyon, C., Faugeron, G., Zickler, D., Rossignol, J.L., Noyer-Weidner, M., Vollmayr, P., Trautner, T.A., Walter, J. Cell (1997) [Pubmed]
  12. TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes. Judson, N., Mekalanos, J.J. Nat. Biotechnol. (2000) [Pubmed]
  13. Broad resistance to plant viruses in transgenic plants conferred by antisense inhibition of a host gene essential in S-adenosylmethionine-dependent transmethylation reactions. Masuta, C., Tanaka, H., Uehara, K., Kuwata, S., Koiwai, A., Noma, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. amfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus. Yamazaki, H., Takano, Y., Ohnishi, Y., Horinouchi, S. Mol. Microbiol. (2003) [Pubmed]
  15. Insertions of mini-Tn10 transposon T-POP in Salmonella enterica sv. typhi. Hidalgo, A.A., Trombert, A.N., Castro-Alonso, J.C., Santiviago, C.A., Tesser, B.R., Youderian, P., Mora, G.C. Genetics (2004) [Pubmed]
  16. Identification of acoR, a regulatory gene for the expression of genes essential for acetoin catabolism in Alcaligenes eutrophus H16. Krüger, N., Steinbüchel, A. J. Bacteriol. (1992) [Pubmed]
  17. Identification of essential components of the S. cerevisiae kinetochore. Doheny, K.F., Sorger, P.K., Hyman, A.A., Tugendreich, S., Spencer, F., Hieter, P. Cell (1993) [Pubmed]
  18. GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Miyajima, I., Nakafuku, M., Nakayama, N., Brenner, C., Miyajima, A., Kaibuchi, K., Arai, K., Kaziro, Y., Matsumoto, K. Cell (1987) [Pubmed]
  19. CDC17: an essential gene that prevents telomere elongation in yeast. Carson, M.J., Hartwell, L. Cell (1985) [Pubmed]
  20. Genetic analysis of yeast RAS1 and RAS2 genes. Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J., Wigler, M. Cell (1984) [Pubmed]
  21. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Cho, H., Mu, J., Kim, J.K., Thorvaldsen, J.L., Chu, Q., Crenshaw, E.B., Kaestner, K.H., Bartolomei, M.S., Shulman, G.I., Birnbaum, M.J. Science (2001) [Pubmed]
  22. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Sun, X., Meyers, E.N., Lewandoski, M., Martin, G.R. Genes Dev. (1999) [Pubmed]
  23. Detection of three novel mutations in two haemophilia A patients by rapid screening of whole essential region of factor VIII gene. Naylor, J.A., Green, P.M., Montandon, A.J., Rizza, C.R., Giannelli, F. Lancet (1991) [Pubmed]
  24. Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins. Bömer, U., Maarse, A.C., Martin, F., Geissler, A., Merlin, A., Schönfisch, B., Meijer, M., Pfanner, N., Rassow, J. EMBO J. (1998) [Pubmed]
  25. ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meiotic and mitotic spindle poles. Matthews, L.R., Carter, P., Thierry-Mieg, D., Kemphues, K. J. Cell Biol. (1998) [Pubmed]
  26. MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. Maarse, A.C., Blom, J., Grivell, L.A., Meijer, M. EMBO J. (1992) [Pubmed]
  27. Capsule loss in H. influenzae type b occurs by recombination-mediated disruption of a gene essential for polysaccharide export. Kroll, J.S., Hopkins, I., Moxon, E.R. Cell (1988) [Pubmed]
  28. tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. Wolf, J., Gerber, A.P., Keller, W. EMBO J. (2002) [Pubmed]
  29. CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. Collart, M.A., Struhl, K. EMBO J. (1993) [Pubmed]
  30. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Buddelmeijer, N., Judson, N., Boyd, D., Mekalanos, J.J., Beckwith, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  31. Inhibition of Escherichia coli viability by external guide sequences complementary to two essential genes. McKinney, J., Guerrier-Takada, C., Wesolowski, D., Altman, S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  32. The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo. Pinto, I., Ware, D.E., Hampsey, M. Cell (1992) [Pubmed]
  33. Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila. Breeden, L., Nasmyth, K. Nature (1987) [Pubmed]
  34. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo. Lee, D., Lis, J.T. Nature (1998) [Pubmed]
  35. An adenosine deaminase that generates inosine at the wobble position of tRNAs. Gerber, A.P., Keller, W. Science (1999) [Pubmed]
  36. Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Reynolds, D., Shi, B.J., McLean, C., Katsis, F., Kemp, B., Dalton, S. Genes Dev. (2003) [Pubmed]
  37. Myogenic specification of side population cells in skeletal muscle. Asakura, A., Seale, P., Girgis-Gabardo, A., Rudnicki, M.A. J. Cell Biol. (2002) [Pubmed]
  38. Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae. Anderson, M.S., Yarger, J.G., Burck, C.L., Poulter, C.D. J. Biol. Chem. (1989) [Pubmed]
  39. Detection of Vi-negative Salmonella enterica serovar typhi in the peripheral blood of patients with typhoid fever in the Faisalabad region of Pakistan. Baker, S., Sarwar, Y., Aziz, H., Haque, A., Ali, A., Dougan, G., Wain, J., Haque, A. J. Clin. Microbiol. (2005) [Pubmed]
  40. GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin gene. Zhang, H., Toyofuku, T., Kamei, J., Hori, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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