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Gene Review

COQ6  -  putative N,N-dimethylaniline monooxygenase...

Saccharomyces cerevisiae S288c

Synonyms: G9165, Ubiquinone biosynthesis monooxygenase COQ6, YGR255C
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High impact information on COQ6

  • We find that steady-state levels of Coq3p, Coq4p, and Coq6p are rescued in some cases to near wild-type levels by the presence of these diverse Coq1 orthologs in the Deltacoq1 mutant [1].
  • Similarly, gel filtration chromatography shows that Coq1p, Coq3p, Coq4p, Coq5p, and Coq6p elute in fractions higher than expected for their respective subunit molecular masses [2].
  • Based on sequence homology to known proteins, we suggest that COQ6 encodes a flavin-dependent monooxygenase required for one or more steps in Q biosynthesis [3].
  • Here we have isolated the COQ6 gene by functional complementation and, in contrast to a previous report, find it is not an essential gene. coq6 mutants are unable to grow on nonfermentable carbon sources and do not synthesize Q but instead accumulate the Q biosynthetic intermediate 3-hexaprenyl-4-hydroxybenzoic acid [3].
  • The Coq6 polypeptide is imported into the mitochondria in a membrane potential-dependent manner [3].

Biological context of COQ6

  • Tetrad analysis of the heterozygous disruptants revealed that ORF YGR255c, previously identified as COQ6 and encoding a protein involved in the biosynthesis of coenzime Q (Tzagoloff and Dieckmann, 1990), is an essential gene [4].
  • In this work we show that a segment of yeast genomic DNA containing ABC1/COQ8 and neighboring genes suppresses the respiratory and Q-deficient phenotypes of the coq6 mutant, coq6-1 [5].

Anatomical context of COQ6


Associations of COQ6 with chemical compounds


  1. Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase. Gin, P., Clarke, C.F. J. Biol. Chem. (2005) [Pubmed]
  2. Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. Marbois, B., Gin, P., Faull, K.F., Poon, W.W., Lee, P.T., Strahan, J., Shepherd, J.N., Clarke, C.F. J. Biol. Chem. (2005) [Pubmed]
  3. The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. Gin, P., Hsu, A.Y., Rothman, S.C., Jonassen, T., Lee, P.T., Tzagoloff, A., Clarke, C.F. J. Biol. Chem. (2003) [Pubmed]
  4. Disruption of six novel genes from chromosome VII of Saccharomyces cerevisiae reveals one essential gene and one gene which affects the growth rate. Fiori, A., Bianchi, M.M., Fabiani, L., Falcone, C., Francisci, S., Palleschi, C., Solimando, N., Uccelletti, D., Frontali, L. Yeast (2000) [Pubmed]
  5. A tRNA(TRP) gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8. Hsieh, E.J., Dinoso, J.B., Clarke, C.F. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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