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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Brefeldin C     (1R,2S,3Z,7S,11Z,13R)-2- hydroxy-7-methyl-6...

Synonyms: AC1O5RDE, 73899-78-2
 
 
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High impact information on Brefeldin C

  • A single Phe/Tyr substitution is sufficient to achieve BFA sensitivity of the Sec7 domain, which is supported by our characterization of brefeldin C (BFC), a BFA analog that cannot interact with the Tyr residue, and by free energy computations [1].
  • Macrolide biosynthesis: stereochemistry of the hydroxylation of brefeldin C [2].

References

  1. Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains. Zeeh, J.C., Zeghouf, M., Grauffel, C., Guibert, B., Martin, E., Dejaegere, A., Cherfils, J. J. Biol. Chem. (2006) [Pubmed]
  2. Macrolide biosynthesis: stereochemistry of the hydroxylation of brefeldin C. Gonzalez de la Parra, M., Hutchinson, C.R. J. Antibiot. (1987) [Pubmed]
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