The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CYTH1  -  cytohesin 1

Homo sapiens

Synonyms: B2-1, CYTOHESIN-1, Cytohesin-1, D17S811E, PH, SEC7 and coiled-coil domain-containing protein 1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of PSCD1

 

High impact information on PSCD1

  • Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase [3].
  • Sec7-related guanine nucleotide exchange factors (GEFs) initiate vesicle budding from the Golgi membrane surface by converting the GTPase ARF to a GTP-bound, membrane-associated form [3].
  • We describe here a protein, cytohesin-1, which specifically interacts with the intracellular portion of the integrin beta 2 chain (CD18) [4].
  • Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains [5].
  • GRP1 and cytohesin-1 appear to connect receptor-activated PI 3-kinase signaling pathways with proteins that mediate biological responses such as cell adhesion and membrane trafficking [5].
 

Chemical compound and disease context of PSCD1

 

Biological context of PSCD1

 

Anatomical context of PSCD1

  • These highly specific cellular effects suggest that the ARF-GEF activity of cytohesin 1 plays an important role in cytoskeletal remodeling events of lymphoid cells [11].
  • In transfected COS-7 cells, overexpressed ARD1 and cytohesin-1 were partially colocalized, as determined by confocal fluorescence microscopy [6].
  • Yeast two-hybrid screening of a B cell library using the cytohesin N terminus as bait, identified CASP, a scaffolding protein of previously unknown function, as a binding partner [12].
  • We therefore propose that both direct regulation of the integrin and concomitant changes in the membrane topology of adherent T cells are modulated by dissectable functions of cytohesin-1 [7].
  • Interestingly, B2-1 does not localize to the plasma membrane but rather associates with a distinct Golgi complex compartment [10].
 

Associations of PSCD1 with chemical compounds

 

Physical interactions of PSCD1

  • Structure-based mutational analysis of the cytohesin-1 Sec7 domain has been used to identify residues important for binding to Arf and for mediating nucleotide exchange [14].
 

Enzymatic interactions of PSCD1

  • Sec7 domains catalyze the replacement of GDP by GTP on the G protein ADP-ribosylation factor 1 (myrARF1) by interacting with its switch I and II regions and by destabilizing, through a glutamic finger, the beta-phosphate of the bound GDP [16].
 

Regulatory relationships of PSCD1

  • Cytohesin is a guanine nucleotide exchange factor that regulates members of the ADP-ribosylation factor (ARF) family of small GTPases [12].
  • Cytohesin-1 also has been reported to promote cellular adhesion via binding to the beta2 integrin cytoplasmic domain [14].
  • Secondly, cytohesin-1 induces expression of an extracellular activation epitope of LFA-1, and the exchange factor function is not essential for this activity [7].
  • Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression [15].
  • Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway [17].
 

Other interactions of PSCD1

  • The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP [12].
  • The effector region of the ARF domain of ARD1 appeared to be critical for the specific interaction with cytohesin-1 [6].
  • Similarly, full-length [35S]mSec7-1/cytohesin was specifically adsorbed to glutathione-Sepharose loaded with glutathione S-transferase (GST)-ARP-Q79L, GST-ARP, or GST-ARP-T31N, the latter exhibiting the lowest binding affinity [18].
  • Overexpression of wild type ARNO significantly increased insulin-stimulated PLD activity, and mutations in the Sec7 and PH domains, or deletion of the PH or CC domains inhibited the effects of insulin [19].
  • Two mRNAs with and without the 3-base pair sequence were found in brain in different ratios for cytohesin-1, -2, and -3 but not cytohesin-4 [9].
 

Analytical, diagnostic and therapeutic context of PSCD1

References

  1. Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain. Pacheco-Rodriguez, G., Meacci, E., Vitale, N., Moss, J., Vaughan, M. J. Biol. Chem. (1998) [Pubmed]
  2. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Kliche, S., Nagel, W., Kremmer, E., Atzler, C., Ege, A., Knorr, T., Koszinowski, U., Kolanus, W., Haas, J. Mol. Cell (2001) [Pubmed]
  3. Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase. Mossessova, E., Gulbis, J.M., Goldberg, J. Cell (1998) [Pubmed]
  4. Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H., Seed, B. Cell (1996) [Pubmed]
  5. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Klarlund, J.K., Guilherme, A., Holik, J.J., Virbasius, J.V., Chawla, A., Czech, M.P. Science (1997) [Pubmed]
  6. Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1). Vitale, N., Pacheco-Rodriguez, G., Ferrans, V.J., Riemenschneider, W., Moss, J., Vaughan, M. J. Biol. Chem. (2000) [Pubmed]
  7. Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. Geiger, C., Nagel, W., Boehm, T., van Kooyk, Y., Figdor, C.G., Kremmer, E., Hogg, N., Zeitlmann, L., Dierks, H., Weber, K.S., Kolanus, W. EMBO J. (2000) [Pubmed]
  8. Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2. Theis, M.G., Knorre, A., Kellersch, B., Moelleken, J., Wieland, F., Kolanus, W., Famulok, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. Ogasawara, M., Kim, S.C., Adamik, R., Togawa, A., Ferrans, V.J., Takeda, K., Kirby, M., Moss, J., Vaughan, M. J. Biol. Chem. (2000) [Pubmed]
  10. B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex. Lee, S.Y., Mansour, M., Pohajdak, B. Exp. Cell Res. (2000) [Pubmed]
  11. Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers. Mayer, G., Blind, M., Nagel, W., Böhm, T., Knorr, T., Jackson, C.L., Kolanus, W., Famulok, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  12. The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. Mansour, M., Lee, S.Y., Pohajdak, B. J. Biol. Chem. (2002) [Pubmed]
  13. Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor. Meacci, E., Tsai, S.C., Adamik, R., Moss, J., Vaughan, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  14. Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. Betz, S.F., Schnuchel, A., Wang, H., Olejniczak, E.T., Meadows, R.P., Lipsky, B.P., Harris, E.A., Staunton, D.E., Fesik, S.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  15. ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells. Bourgoin, S.G., Houle, M.G., Singh, I.N., Harbour, D., Gagnon, S., Morris, A.J., Brindley, D.N. J. Leukoc. Biol. (2002) [Pubmed]
  16. Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange. Béraud-Dufour, S., Paris, S., Chabre, M., Antonny, B. J. Biol. Chem. (1999) [Pubmed]
  17. Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway. Chen, Q., Coffey, A., Bourgoin, S.G., Gadina, M. J. Biol. Chem. (2006) [Pubmed]
  18. The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D. Schürmann, A., Schmidt, M., Asmus, M., Bayer, S., Fliegert, F., Koling, S., Massmann, S., Schilf, C., Subauste, M.C., Voss, M., Jakobs, K.H., Joost, H.G. J. Biol. Chem. (1999) [Pubmed]
  19. The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin. Li, H.S., Shome, K., Rojas, R., Rizzo, M.A., Vasudevan, C., Fluharty, E., Santy, L.C., Casanova, J.E., Romero, G. BMC Cell Biol. (2003) [Pubmed]
  20. A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1. Béraud-Dufour, S., Robineau, S., Chardin, P., Paris, S., Chabre, M., Cherfils, J., Antonny, B. EMBO J. (1998) [Pubmed]
  21. EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. Venkateswarlu, K., Gunn-Moore, F., Tavaré, J.M., Cullen, P.J. J. Cell. Sci. (1999) [Pubmed]
  22. Characterization of cytohesin-1 monoclonal antibodies: expression in neutrophils and during granulocytic maturation of HL-60 cells. Garceau, V., Houle, M.G., Chouinard, F., Gagnon, S., Harbour, D., Naccache, P.H., Bourgoin, S.G. J. Immunol. Methods (2001) [Pubmed]
  23. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Dixon, B., Mansour, M., Pohajdak, B. Cytogenet. Cell Genet. (1993) [Pubmed]
 
WikiGenes - Universities