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Chemical Compound Review: 

leukotriene B3     (5R,6E,8Z,10E,12S)-5,12- dihydroxyicosa-6,8...

Synonyms: LTB3, AC1O5RQZ, 88099-35-8
 
 
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High impact information on leukotriene B3

  • Insignificant amounts of 5(S), 12(R)-dihydroxy-6-cis-8,10-trans-eicosatrienoic acid (leukotriene B3) were formed by incubation of rat neutrophils with leukotriene A3 or by the purified rat and human LTA4 hydrolases incubated with leukotriene A3 [1].
  • Neutrophils from rats fed a normal diet incubated with ionophore and exogenous 5,8,11-eicosatrienoate also produced leukotriene A3 and its nonenzymatic degradation products but little or no leukotriene B3 [2].
  • The sulphidopeptide leukotrienes have potent biological actions including effects on smooth muscle, mucus secretion and vascular permeability whereas leukotriene B3 is a powerful chemoattractant for neutrophils [3].

References

  1. Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase. Evans, J.F., Nathaniel, D.J., Zamboni, R.J., Ford-Hutchinson, A.W. J. Biol. Chem. (1985) [Pubmed]
  2. Leukotriene B formation by neutrophils from essential fatty acid-deficient rats. Stenson, W.F., Prescott, S.M., Sprecher, H. J. Biol. Chem. (1984) [Pubmed]
  3. The role of leukotrienes in asthma. Leitch, A.G. Ann. Acad. Med. Singap. (1985) [Pubmed]
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