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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

CHEMBL147909     (Z)-N-[[4-(2-aminoethoxy)-3- methoxy...

Synonyms: SureCN6700365, CHEBI:343529, NE-21610, AC1O5UW3, NE 21610, ...
 
 
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Disease relevance of NE 21610

  • The present study examined whether pretreatment of the skin with NE-21610 prevents the development of hyperalgesia following heat injury [1].
 

High impact information on NE 21610

  • Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man [2].
  • All three compounds were extensively metabolized during passage through fresh SkH:Fz rat skin, with the primary route of degradation for at least two of the compounds involving hydrolysis of the amide bond (the metabolites of NE-21610 were not identified) [3].
 

Chemical compound and disease context of NE 21610

 

Analytical, diagnostic and therapeutic context of NE 21610

  • The present study examined the effects of cutaneous NE-21610 on heat and mechanical sensation in normal human volunteers [2].
  • On the 1st day testing, 7 volunteers received a 30-microl intradermal injection of vehicle to one volar forearm and 10 micrograms of NE-21610 to the other volar forearm [1].

References

  1. Cutaneous pretreatment with the capsaicin analog NE-21610 prevents the pain to a burn and subsequent hyperalgesia. Davis, K.D., Meyer, R.A., Turnquist, J.L., Filloon, T.G., Pappagallo, M., Campbell, J.N. Pain (1995) [Pubmed]
  2. Cutaneous injection of the capsaicin analogue, NE-21610, produces analgesia to heat but not to mechanical stimuli in man. Davis, K.D., Meyer, R.A., Turnquist, J.L., Filloon, T.G., Pappagallo, M., Campbell, J.N. Pain (1995) [Pubmed]
  3. Percutaneous absorption of vanilloids: in vivo and in vitro studies. Kasting, G.B., Francis, W.R., Bowman, L.A., Kinnett, G.O. Journal of pharmaceutical sciences. (1997) [Pubmed]
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