Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O5ZQ8 [5-(6-aminopurin-9-yl)-2- [[[[3-[2-[2-[(E)...

Synonyms: 59862-14-5, 5-Hydroxyferuloyl coa, 5-Hydroxyferuloyl-coenzyme A

Meng, H. et al., Busam, G. et al., Patten, A.M. et al.

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Disease relevance of 5-Hydroxyferuloyl-coenzyme A

The expression of the cDNA in Escherichia coli revealed that grapevine CCoAOMT methylates both caffeoyl- and 5-hydroxyferuloyl-coenzyme A and is probably involved in phenolic esterification and lignification [1].

High impact information on 5-Hydroxyferuloyl-coenzyme A

Caffeate O-methyltransferase is more likely to be responsible for lignin precursor biosynthesis in the syringyl pathway, especially since it can catalyze methylation of 5-hydroxyferuloyl-CoA quite effectively [2].
Recombinant CCR1 displayed fairly broad substrate versatility for all phenylpropanoid CoA substrates, with both feruloyl and 5-hydroxyferuloyl CoA being the best substrates [3].

References

Characterization and expression of caffeoyl-coenzyme A 3-O-methyltransferase proposed for the induced resistance response of Vitis vinifera L. Busam, G., Junghanns, K.T., Kneusel, R.E., Kassemeyer, H.H., Matern, U. Plant Physiol. (1997) [Pubmed]
Substrate profiles and expression of caffeoyl coenzyme A and caffeic acid O-methyltransferases in secondary xylem of aspen during seasonal development. Meng, H., Campbell, W.H. Plant Mol. Biol. (1998) [Pubmed]
Reassessment of effects on lignification and vascular development in the irx4 Arabidopsis mutant. Patten, A.M., Cardenas, C.L., Cochrane, F.C., Laskar, D.D., Bedgar, D.L., Davin, L.B., Lewis, N.G. Phytochemistry (2005) [Pubmed]

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