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Chemical Compound Review

ddeCyd     4-amino-1-[(2R,5R)-5- (hydroxymethyl)-2,5...

Synonyms: SureCN5821, CHEMBL2115278, LS-59076, AC1L21QE, C9H11N3O3, ...
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Disease relevance of ddeCyd


High impact information on ddeCyd

  • In ATH8 cells ddCyd, ddeCyd, and ddAdo had the highest therapeutic index whereas in MT4 cells AzddThd, ddThd, ddCyd, and ddAdo were the most selective [3].


  1. The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides. Balzarini, J., Kang, G.J., Dalal, M., Herdewijn, P., De Clercq, E., Broder, S., Johns, D.G. Mol. Pharmacol. (1987) [Pubmed]
  2. Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues. Stuyver, L.J., Lostia, S., Adams, M., Mathew, J.S., Pai, B.S., Grier, J., Tharnish, P.M., Choi, Y., Chong, Y., Choo, H., Chu, C.K., Otto, M.J., Schinazi, R.F. Antimicrob. Agents Chemother. (2002) [Pubmed]
  3. 3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. Herdewijn, P., Balzarini, J., De Clercq, E., Pauwels, R., Baba, M., Broder, S., Vanderhaeghe, H. J. Med. Chem. (1987) [Pubmed]
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