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Chemical Compound Review:

ddeCyd 4-amino-1-[(2R,5R)-5- (hydroxymethyl)-2,5...

Synonyms: SureCN5821, CHEMBL2115278, LS-59076, AC1L21QE, C9H11N3O3, ...

Balzarini, J. et al., Herdewijn, P. et al., Stuyver, L.J. et al.

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Disease relevance of ddeCyd

All ddeNs except ddeUrd are potent and/or selective inhibitors of human immunodeficiency virus (HIV) in vitro, ddeCyd being the most potent (MIC50, 0.30 microM) [1].
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues [2].

High impact information on ddeCyd

In ATH8 cells ddCyd, ddeCyd, and ddAdo had the highest therapeutic index whereas in MT4 cells AzddThd, ddThd, ddCyd, and ddAdo were the most selective [3].

References

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides. Balzarini, J., Kang, G.J., Dalal, M., Herdewijn, P., De Clercq, E., Broder, S., Johns, D.G. Mol. Pharmacol. (1987) [Pubmed]
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues. Stuyver, L.J., Lostia, S., Adams, M., Mathew, J.S., Pai, B.S., Grier, J., Tharnish, P.M., Choi, Y., Chong, Y., Choo, H., Chu, C.K., Otto, M.J., Schinazi, R.F. Antimicrob. Agents Chemother. (2002) [Pubmed]
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. Herdewijn, P., Balzarini, J., De Clercq, E., Pauwels, R., Baba, M., Broder, S., Vanderhaeghe, H. J. Med. Chem. (1987) [Pubmed]

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