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Chemical Compound Review:

Bourgeonal 3-(4-tert-butylphenyl)propanal

Synonyms: AG-C-30852, ALBB-005196, ANW-45671, AK-88703, KB-75191, ...

Spehr, M. et al., Spehr, M. et al.

Spehr, Schwane, Riffell, Barbour, Zimmer, Neuhaus, Hatt,

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High impact information on Bourgeonal

Upon incubation with SQ22536, cells ceased to exhibit Ca(2+) signaling, chemotaxis, and hyperactivation (faster swim speed and flagellar beat rate) in response to bourgeonal [1].
Certain floral scents, including bourgeonal, activate hOR17-4, trigger pronounced Ca(2+) fluxes, and evoke chemotaxis [1].

Analytical, diagnostic and therapeutic context of Bourgeonal

Bourgeonal was a powerful agonist for both recombinant and native receptor types, as well as a strong chemoattractant in subsequent behavioral bioassays [2].

References

Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. Spehr, M., Schwane, K., Riffell, J.A., Barbour, J., Zimmer, R.K., Neuhaus, E.M., Hatt, H. J. Biol. Chem. (2004) [Pubmed]
Identification of a testicular odorant receptor mediating human sperm chemotaxis. Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J.A., Wetzel, C.H., Zimmer, R.K., Hatt, H. Science (2003) [Pubmed]

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