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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Chemotaxis


Psychiatry related information on Chemotaxis


High impact information on Chemotaxis


Chemical compound and disease context of Chemotaxis


Biological context of Chemotaxis


Anatomical context of Chemotaxis


Associations of Chemotaxis with chemical compounds


Gene context of Chemotaxis

  • When coexpressed in cells with KDR, neuropilin-1 enhances the binding of VEGF165 to KDR and VEGF165-mediated chemotaxis [28].
  • SDF-1 induced an increase in intracellular free Ca2+ and chemotaxis in CXCR-4-transfected cells [29].
  • We show that BLC stimulates calcium influx into, and chemotaxis of, cells transfected with BLR-1 [30].
  • Here we describe the isolation of a mutant, ky542, with specific defects in odour discrimination and odour chemotaxis. ky542 is an allele of nsy-1, a neuronal symmetry, or Nsy, mutant in which STR-2 is expressed in both AWC neurons [31].
  • A derivative of RANTES that was created by chemical modification of the amino terminus, aminooxypentane (AOP)-RANTES, did not induce chemotaxis and was a subnanomolar antagonist of CCR5 function in monocytes [32].

Analytical, diagnostic and therapeutic context of Chemotaxis


  1. Multiple methylation of methyl-accepting chemotaxis proteins during adaptation of E. coli to chemical stimuli. Engström, P., Hazelbauer, G.L. Cell (1980) [Pubmed]
  2. Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. Boxer, L.A., Watanabe, A.M., Rister, M., Besch, H.R., Allen, J., Baehner, R.L. N. Engl. J. Med. (1976) [Pubmed]
  3. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Swingler, S., Mann, A., Jacqué, J., Brichacek, B., Sasseville, V.G., Williams, K., Lackner, A.A., Janoff, E.N., Wang, R., Fisher, D., Stevenson, M. Nat. Med. (1999) [Pubmed]
  4. Geobacter metallireducens accesses insoluble Fe(III) oxide by chemotaxis. Childers, S.E., Ciufo, S., Lovley, D.R. Nature (2002) [Pubmed]
  5. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Yang, D., Chertov, O., Bykovskaia, S.N., Chen, Q., Buffo, M.J., Shogan, J., Anderson, M., Schröder, J.M., Wang, J.M., Howard, O.M., Oppenheim, J.J. Science (1999) [Pubmed]
  6. Effect of age on adherence and chemotaxis capacities of peritoneal macrophages. Influence of physical activity stress. Forner, M.A., Collazos, M.E., Barriga, C., De la Fuente, M., Rodriguez, A.B., Ortega, E. Mech. Ageing Dev. (1994) [Pubmed]
  7. Immunologic abnormalities in the acquired immunodeficiency syndrome. Lane, H.C., Fauci, A.S. Annu. Rev. Immunol. (1985) [Pubmed]
  8. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P., Snyder, S.H. Cell (2003) [Pubmed]
  9. Adenylyl cyclase localization regulates streaming during chemotaxis. Kriebel, P.W., Barr, V.A., Parent, C.A. Cell (2003) [Pubmed]
  10. PI 3-kinases and PTEN: how opposites chemoattract. Comer, F.I., Parent, C.A. Cell (2002) [Pubmed]
  11. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Robbiani, D.F., Finch, R.A., Jäger, D., Muller, W.A., Sartorelli, A.C., Randolph, G.J. Cell (2000) [Pubmed]
  12. Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor. Kim, K.K., Yokota, H., Kim, S.H. Nature (1999) [Pubmed]
  13. Activation of bacterial porin gene expression by a chimeric signal transducer in response to aspartate. Utsumi, R., Brissette, R.E., Rampersaud, A., Forst, S.A., Oosawa, K., Inouye, M. Science (1989) [Pubmed]
  14. Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice. Abraham, E., Bursten, S., Shenkar, R., Allbee, J., Tuder, R., Woodson, P., Guidot, D.M., Rice, G., Singer, J.W., Repine, J.E. J. Exp. Med. (1995) [Pubmed]
  15. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. Cronstein, B.N., Daguma, L., Nichols, D., Hutchison, A.J., Williams, M. J. Clin. Invest. (1990) [Pubmed]
  16. Induction of heat-shock protein 72 protects against ischemia/reperfusion in rat small intestine. Stojadinovic, A., Kiang, J., Smallridge, R., Galloway, R., Shea-Donohue, T. Gastroenterology (1995) [Pubmed]
  17. Mutants defective in bacterial chemotaxis show modified protein phosphorylation. Oosawa, K., Hess, J.F., Simon, M.I. Cell (1988) [Pubmed]
  18. Cellular serine proteinase induces chemotaxis by complement activation. Thomas, C.A., Yost, F.J., Snyderman, R., Hatcher, V.B., Lazarus, G.S. Nature (1977) [Pubmed]
  19. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Lee, M.J., Thangada, S., Paik, J.H., Sapkota, G.P., Ancellin, N., Chae, S.S., Wu, M., Morales-Ruiz, M., Sessa, W.C., Alessi, D.R., Hla, T. Mol. Cell (2001) [Pubmed]
  20. Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation. Soriano, S.F., Hernanz-Falcón, P., Rodríguez-Frade, J.M., De Ana, A.M., Garzón, R., Carvalho-Pinto, C., Vila-Coro, A.J., Zaballos, A., Balomenos, D., Martínez-A, C., Mellado, M. J. Exp. Med. (2002) [Pubmed]
  21. Neutrophil-activating properties of the melanoma growth-stimulatory activity. Moser, B., Clark-Lewis, I., Zwahlen, R., Baggiolini, M. J. Exp. Med. (1990) [Pubmed]
  22. Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. Pike, M.C., Snyderman, R. Cell (1982) [Pubmed]
  23. The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. Chen, A., Ganor, Y., Rahimipour, S., Ben-Aroya, N., Koch, Y., Levite, M. Nat. Med. (2002) [Pubmed]
  24. Evidence for positional differentiation of prestalk cells and for a morphogenetic gradient in Dictyostelium. Early, A., Abe, T., Williams, J. Cell (1995) [Pubmed]
  25. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., Shimizu, T. Nature (1997) [Pubmed]
  26. Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis. Stock, A.M., Mottonen, J.M., Stock, J.B., Schutt, C.E. Nature (1989) [Pubmed]
  27. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Partida-Sánchez, S., Cockayne, D.A., Monard, S., Jacobson, E.L., Oppenheimer, N., Garvy, B., Kusser, K., Goodrich, S., Howard, M., Harmsen, A., Randall, T.D., Lund, F.E. Nat. Med. (2001) [Pubmed]
  28. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Soker, S., Takashima, S., Miao, H.Q., Neufeld, G., Klagsbrun, M. Cell (1998) [Pubmed]
  29. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Bleul, C.C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., Sodroski, J., Springer, T.A. Nature (1996) [Pubmed]
  30. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Gunn, M.D., Ngo, V.N., Ansel, K.M., Ekland, E.H., Cyster, J.G., Williams, L.T. Nature (1998) [Pubmed]
  31. C. elegans odour discrimination requires asymmetric diversity in olfactory neurons. Wes, P.D., Bargmann, C.I. Nature (2001) [Pubmed]
  32. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Simmons, G., Clapham, P.R., Picard, L., Offord, R.E., Rosenkilde, M.M., Schwartz, T.W., Buser, R., Wells, T.N., Proudfoot, A.E. Science (1997) [Pubmed]
  33. Serum inhibitor of C5 fragment-mediated polymorphonuclear leukocyte chemotaxis associated with chronic hemodialysis. Goldblum, S.E., Van Epps, D.E., Reed, W.P. J. Clin. Invest. (1979) [Pubmed]
  34. The effect of neutrophil migration on epithelial permeability. Milks, L.C., Conyers, G.P., Cramer, E.B. J. Cell Biol. (1986) [Pubmed]
  35. Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. Rabinovitz, I., Toker, A., Mercurio, A.M. J. Cell Biol. (1999) [Pubmed]
  36. Adaptational "crosstalk" and the crucial role of methylation in chemotactic migration by Escherichia coli. Hazelbauer, G.L., Park, C., Nowlin, D.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  37. The identification of the mot gene product with Escherichia coli-lambda hybrids. Silverman, M., Matsumura, P., Simon, M. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
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