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Chemical Compound Review:

AraCMP [(2R,3S,4S,5R)-5-(4-amino-2- oxo-pyrimidin...

Synonyms: Ara-CMP, CHEMBL596186, C6760_SIGMA, CHEBI:41343, SureCN11217191, ...

Mikita, T. et al., Braess, J. et al.

Braess, Wegendt, Feuring-Buske, Riggert, Kern, Hiddemann, Schleyer,

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Disease relevance of AraCMP

AraCMP at the primer terminus dramatically reduced the rate of next nucleotide addition for Escherichia coli polymerase I (Klenow fragment) (Pol I), T4 polymerase, HeLa cell polymerase alpha 2 (Pol alpha 2), and AMV reverse transcriptase [1].

High impact information on AraCMP

AraCMP located at an internucleotide site in the template markedly slowed replicative bypass for Pol I, T4 polymerase, and Pol alpha 2, but not for reverse transcriptase [1].
Highly significant differences were found for phosphorylated AraC metabolites (AraCMP, -CDP, -CTP, AraUMP) between AML and normal mononuclear bone marrow (ng/107 cells respectively 1.30 v 2.66; 2.65 v 7.50; 33.68 v 99.0; 1.18 v 5.70) [2].

References

Functional consequences of the arabinosylcytosine structural lesion in DNA. Mikita, T., Beardsley, G.P. Biochemistry (1988) [Pubmed]
Leukaemic blasts differ from normal bone marrow mononuclear cells and CD34+ haemopoietic stem cells in their metabolism of cytosine arabinoside. Braess, J., Wegendt, C., Feuring-Buske, M., Riggert, J., Kern, W., Hiddemann, W., Schleyer, E. Br. J. Haematol. (1999) [Pubmed]

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