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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

ERVK2  -  endogenous retroviral sequence K(C4), 2

Homo sapiens

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Disease relevance of ERVK2

 

Psychiatry related information on ERVK2

 

High impact information on ERVK2

 

Chemical compound and disease context of ERVK2

 

Biological context of ERVK2

  • PATIENTS AND METHODS: A sensitive methylation-specific polymerase chain reaction assay was used to evaluate 14-3-3sigma methylation status in pretreatment serum DNA obtained from 115 cisplatin-plus-gemcitabine-treated advanced NSCLC patients [20].
  • No correlation was observed between the degree of genetic complexity of HCV (indicated by the number of bands in the SSCP assay) and patient age, serum alanine aminotransferase activity, or serum HCV-RNA concentration, measured by competitive polymerase chain reaction [21].
  • To address these questions, stored mucin in the epithelium and goblet cell size and number were measured morphometrically, and mucin gene expression was measured by polymerase chain reaction and immunohistochemistry in endobronchial biopsies from 13 subjects with mild and moderate asthma and from 12 healthy control subjects [22].
  • In nonmuscle tissues (brain, liver, kidney, lung), the transgene expression was extremely low even though in these tissues in situ polymerase chain reaction showed as high an infectivity of the cells by the AV as in muscle [23].
  • 5A/6A genotype in the stromelysin-1 promoter was determined using polymerase chain reaction and direct sequencing [24].
 

Anatomical context of ERVK2

 

Associations of ERVK2 with chemical compounds

  • This polypeptide co-sediments with polymerase activity through a glycerol gradient [30].
  • The MICA transmembrane polymorphism in exon 5 was analyzed after biotin-labeled polymerase chain reaction products were loaded onto sequencing gels and subjected to autoradiography [31].
  • Genetic analysis of the resistant isolates showed that each contained a well-known ganciclovir resistance mutation in the viral UL97 phosphotransferase sequence, as well as a mutation (Ala to Val at codon 809, V809) in conserved region III of the DNA polymerase (Pol) sequence [15].
  • The detection limit of the LC assay was determined with 10-fold dilutions of plasmid pS4 with the SalI restriction fragment of the DNA polymerase gene and with the First European Union Concerted Action HSV Proficiency Panel [32].
  • Fasting plasma homocysteine levels were determined by high-performance liquid chromatography, while genotypes of the MTHFR C677T mutation were determined by polymerase chain reaction [33].
 

Physical interactions of ERVK2

  • The purified fraction has no significant endonuclease activity, but a strong exonuclease activity co-purifies with polymerase activity through every step in the isolation [30].
  • We show that XPG interacts with elongating RNA polymerase II (RNAPII) in the cell and binds stalled RNAPII ternary complexes in vitro both independently and cooperatively with CSB [34].
  • Knockdown of p50 expression with specific small hairpin RNAs reduces HDAC1 binding to the latent HIV LTR and induces RNA polymerase II recruitment [35].
  • We show here that WRN functionally interacts with DNA polymerase delta (pol delta), a eukaryotic polymerase required for DNA replication and DNA repair [36].
  • The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity [37].
 

Enzymatic interactions of ERVK2

  • In addition, antibodies raised against the 40-kDa subunit abolished the A1- and PCNA-dependent synthesis of DNA catalyzed by polymerase delta [38].
  • CDK9 is able to hyperphosphorylate the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase during elongation [39].
  • Both Cdk9 and cyclin T1 showed only limited colocalization with different phosphorylated forms of RNA polymerase II [40].
  • Phosphorylation was carried out using immobilized Cdc2 so that the kinase could be removed from the phosphorylated polymerase [41].
  • In this study we demonstrated that a set of cellular cofactors that modulate the binding of the cellular protein TRP-185 to the TAR RNA loop sequences also functioned to markedly stimulate the specific binding of hypophosphorylated (IIa) and hyperphosphorylated (IIo) RNA polymerase II to TAR RNA [42].
 

Co-localisations of ERVK2

 

Regulatory relationships of ERVK2

  • Recombinant PCNA stimulated human DNA polymerase delta activity at least 25-fold with poly(dA)/oligo-(dT) as the template [48].
  • In this study, we have determined the somatostatin receptor subtypes expressed in various endocrine tumors using a reverse transcriptase polymerase chain reaction method [49].
  • Experiments in which activators were exchanged between initiation and elongation demonstrate that the elongation function of HSF1 will stimulate RNA polymerase that has initiated and is transcriptionally engaged [50].
  • METHODS AND RESULTS: AMPD1 genotype was determined in 132 patients with advanced CHF and 91 control reference subjects by use of a polymerase chain reaction-based, allele-specific oligonucleotide detection assay [51].
  • Here, we show for the first time that both UBF1 and UBF2 activate RNA polymerase II-regulated promoters [52].
 

Other interactions of ERVK2

 

Analytical, diagnostic and therapeutic context of ERVK2

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  21. Relationship of the genomic complexity of hepatitis C virus with liver disease severity and response to interferon in patients with chronic HCV genotype 1b infection [correction of interferon]. López-Labrador, F.X., Ampurdanès, S., Giménez-Barcons, M., Guilera, M., Costa, J., Jiménez de Anta, M.T., Sánchez-Tapias, J.M., Rodés, J., Sáiz, J.C. Hepatology (1999) [Pubmed]
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