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Chemical Compound Review:

Endixaprina 1-[6-(2,4- dichlorophenyl)pyridazin-3...

Synonyms: Endixaprine, Endixaprinum, CHEMBL122858, SureCN2110989, SR-41378, ...

Santucci, V. et al., Perio, A. et al.

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High impact information on Endixaprine

Two amino-phenyl-pyridazine derivatives, SR 41378 and CM 40907, have been reported to antagonize seizures in mice, rats and Papio papio baboons with comparable potencies [1].
In vitro SR 41378 did not interact with benzodiazepine receptor sites [1].

Analytical, diagnostic and therapeutic context of Endixaprine

Quantitative electroencephalographic (QEEG) analysis was performed in rats following the oral administration of SR 41378 [3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine], a novel aminopyridazine derivative, which has been shown to possess anticonvulsant, antianxiety and hypnotic activities in mice and rats [2].

References

Evaluation of two anticonvulsant amino-pyridazine derivatives in the conflict test in rats. Perio, A., Chambon, J.P., Calassi, R., Heaulme, M., Biziere, K. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
Quantitative electroencephalographic profile of 3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine (SR 41378) in the rat. Santucci, V., Rocher, D., Veyrun, J., Bizière, K. Naunyn Schmiedebergs Arch. Pharmacol. (1986) [Pubmed]

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