Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

PubChem18071 1,6-naphthyridine

Synonyms: SureCN139749, ACMC-1CHVM, AG-B-77081, CHEBI:36627, ANW-25710, ...

Jin, H. et al., Bedard, J. et al.

Bedard, May, L'Heureux, Stamminger, Copsey, Drach, Huffman, Chan, Jin, Rando, Jin, Cai, Schacherer, Jabri, Tsiang, Fardis, Chen, Chen, Kim,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 1,6-naphthyridine

Antiviral properties of a series of 1,6-naphthyridine and 7, 8-dihydroisoquinoline derivatives exhibiting potent activity against human cytomegalovirus [1].
A novel class of tri-cyclic HIV integrase inhibitors were designed based on conformational analysis of 1,6-naphthyridine carboxamide compound L-870810 and docking the designed inhibitor into the active site of our integrase enzyme model [2].

References

Antiviral properties of a series of 1,6-naphthyridine and 7, 8-dihydroisoquinoline derivatives exhibiting potent activity against human cytomegalovirus. Bedard, J., May, S., L'Heureux, L., Stamminger, T., Copsey, A., Drach, J., Huffman, J., Chan, L., Jin, H., Rando, R.F. Antimicrob. Agents Chemother. (2000) [Pubmed]
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors. Jin, H., Cai, R.Z., Schacherer, L., Jabri, S., Tsiang, M., Fardis, M., Chen, X., Chen, J.M., Kim, C.U. Bioorg. Med. Chem. Lett. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share