Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

guanylic acid [(2R,3S,4R,5R)-5-(2-amino-6- oxo-3H-purin-9...

Synonyms: guanylate, Xylo-GMP, SureCN5854, 5'-Gmp, 5'-Guanylic acid, ...

Fujio, T. et al., Balaji, P.V. et al., Tsunemori, H. et al., Schr??der, S. et al.

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Disease relevance of guanosine monophosphate

High level expression of XMP aminase in Escherichia coli and its application for the industrial production of 5'-guanylic acid [1].

High impact information on guanosine monophosphate

Adsorptive behavior of the ionic species of the structural analogues, inosine-5'-monophosphoric acid (IMP) and guanosine-5'-monophosphoric acid (GMP), could be controlled by changing the pH condition [2].
The three-dimensional structures of ribonuclease (RNase) T1 complexes with the inhibitors 2'-guanylic acid (2'-GMP), 3'-guanylic acid (3'-GMP), and 5'-guanylic acid (5'-GMP) were predicted by energy minimization studies [3].
Furthermore chlorpromazine was irradiated in the presence of guanosine-5-monophosphate (GMP) in pH 7 buffered solution, leading to a new photoproduct [4].
To improve the efficiency of the enzymatic conversion of 5'-xanthylic acid (XMP) to 5'-guanylic acid (GMP), we attempted to increase the activity of the conversion enzyme, XMP aminase (GMP synthetase) encoded by the guaA gene in Escherichia coli [1].

References

High level expression of XMP aminase in Escherichia coli and its application for the industrial production of 5'-guanylic acid. Fujio, T., Nishi, T., Ito, S., Maruyama, A. Biosci. Biotechnol. Biochem. (1997) [Pubmed]
Surface imprinting polymers for the recognition of nucleotides. Tsunemori, H., Araki, K., Uezu, K., Goto, M., Furusaki, S. Bioseparation (2001) [Pubmed]
Computer modeling studies of ribonuclease T1-guanosine monophosphate complexes. Balaji, P.V., Saenger, W., Rao, V.S. Biopolymers (1990) [Pubmed]
Phototoxicity testing by online irradiation and HPLC. Schr??der, S., Surmann, J.P. Analytical and bioanalytical chemistry (2006) [Pubmed]

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