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Chemical Compound Review

SureCN94114     [(2R,3S,4R,5R)-5-(2-amino-6- oxo-3H-purin-9...

Synonyms: AG-B-22747, Guo-3'-P, CHEBI:28072, AC1Q6MUT, CTK7J7605, ...
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Disease relevance of guanosine monophosphate

  • The crystal structures of ribonuclease from Streptomyces aureofaciens (RNase Sa) and its complex with 3'-guanylic acid (guanosine 3'-monophosphate, 3'-GMP) have been determined by the method of isomorphous replacement [1].
  • The glycosyl torsion angle favors a value in the +syn range in the 2'-GMP (C2'-endo)-RNase T1, 3'-GMP (C2'-endo)-RNase T1, and 3'-GMP (C3'-endo)-RNase T1 complexes; in the high-syn range in the 2'-GMP (C3'-endo)-RNase T1 complex; and in the -syn range in the 5'-GMP (C2'-endo)-RNase T1 and 5'-GMP (C3'-endo)-RNase T1 complexes [2].

High impact information on guanosine monophosphate


Biological context of guanosine monophosphate

  • On the other hand, alkylation of histidine-40 was slowed down most in the presence of 3'-GMP [7].

Associations of guanosine monophosphate with other chemical compounds

  • In the presence of a competitive inhibitor, guanosine 3'-monophosphate (3'-GMP), the rate of RNase inactivation by iodoacetate was reduced significantly [8].
  • The chemical shift changes upon binding of phosphate, guanosine, 2'-GMP, 3'-GMP, 5'-GMP, and guanosine 3',5'-bis(phosphate) were observed as high field shifted methyl proton resonances of RNase T1 [9].
  • The base recognition scheme is identical in both complexes but in RNase T1 X 3'-GMP, the ribose phosphate is not seen in the electron density, probably due to static disorder [10].
  • When RNase U1 was treated with a large excess of phenylglyoxal, the enzymatic activity and binding ability toward 3'-GMP were lost, with simultaneous modification of about 1 residue of arginine [11].

Gene context of guanosine monophosphate

  • The crystal structure of RNase T1 complexed with 3'-GMP has been determined [12].

Analytical, diagnostic and therapeutic context of guanosine monophosphate

  • The pKa for His-91 was shifted to the alkaline side in the presence of 3'-GMP, a competitive inhibitor, in the titration plots observed by both hydrogen-tritium exchange and 1H NMR spectroscopy [13].


  1. Determination and restrained least-squares refinement of the structures of ribonuclease Sa and its complex with 3'-guanylic acid at 1.8 A resolution. Sevcik, J., Dodson, E.J., Dodson, G.G. Acta Crystallogr., B (1991) [Pubmed]
  2. Computer modeling studies of ribonuclease T1-guanosine monophosphate complexes. Balaji, P.V., Saenger, W., Rao, V.S. Biopolymers (1990) [Pubmed]
  3. Crystal structure of RNase T1 with 3'-guanylic acid and guanosine. Zegers, I., Haikal, A.F., Palmer, R., Wyns, L. J. Biol. Chem. (1994) [Pubmed]
  4. Purification of a primase activity associated with DNA polymerase alpha from HeLa cells. Gronostajski, R.M., Field, J., Hurwitz, J. J. Biol. Chem. (1984) [Pubmed]
  5. Crystallization of a complex between ribonuclease Ms and 3'-guanylic acid. Nonaka, T., Mitsui, Y., Nakamura, K.T., Watanabe, H., Ohgi, K., Irie, M. J. Mol. Biol. (1989) [Pubmed]
  6. Protein dynamics. A time-resolved fluorescence, energetic and molecular dynamics study of ribonuclease T1. MacKerell, A.D., Rigler, R., Nilsson, L., Hahn, U., Saenger, W. Biophys. Chem. (1987) [Pubmed]
  7. The structure and function of ribonuclease T1. XXI. Modification of histidine residues in ribonuclease T1 with iodoacetamide. Takahashi, K. J. Biochem. (1976) [Pubmed]
  8. Identification of active-site histidine residues of a self-incompatibility ribonuclease from a wild tomato. Parry, S., Newbigin, E., Currie, G., Bacic, A., Oxley, D. Plant Physiol. (1997) [Pubmed]
  9. Binding modes of inhibitors to ribonuclease T1 as studied by nuclear magnetic resonance. Inagaki, F., Shimada, I., Miyazawa, T. Biochemistry (1985) [Pubmed]
  10. Three-dimensional structure of the ribonuclease T1 X 3'-guanylic acid complex at 2.6 A resolution. Sugio, S., Oka, K., Ohishi, H., Tomita, K., Saenger, W. FEBS Lett. (1985) [Pubmed]
  11. Chemical modifications of ribonuclease U1. Hashimoto, J., Takahashi, K. J. Biochem. (1977) [Pubmed]
  12. Crystal structure of RNase T1 complexed with the product nucleotide 3'-GMP. Structural evidence for direct interaction of histidine 40 and glutamic acid 58 with the 2'-hydroxyl group of the ribose. Gohda, K., Oka, K., Tomita, K., Hakoshima, T. J. Biol. Chem. (1994) [Pubmed]
  13. Hydrogen-tritium exchange and nuclear magnetic resonance titrations of the histidine residues in ribonuclease St and analysis of their microenvironment. Miyamoto, K., Arata, Y., Matsuo, H., Narita, K. J. Biochem. (1981) [Pubmed]
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