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Chemical Compound Review:

deuteride deuterium(-1) anion

Synonyms: AC1OAGLW, CHEBI:29301, D(-), d(+)(e(-))2, (2)H(-), ...

Northcutt, T.O. et al., Bhushan, B. et al., Arabshahi, A. et al., Pang, J. et al., Zhang, Q.A. et al.

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Disease relevance of deuteride

Simulations of hydride and deuteride transfer catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) are presented [1].

High impact information on deuteride

Therefore, hydride transfer becomes rate-limiting at pH extremes but is not limiting at neutral pH, although deuteride transfer is significantly limiting at all pH values [2].
These same reactions were studied by preparing the corresponding metal deuteride complexes, Tp'Rh(L)(R)D, and the scrambling of the deuterium label into the alpha- and omega-positions of the alkyl group monitored by (2)H NMR spectroscopy [3].
In a comparative study with LC-MS, using deuterated and non-deuterated NAD(P)H, we found a positive mass-shift of 1Da in the N-denitrohydrogenated product suggesting the involvement of a deuteride (D(-)) transfer from NAD(P)D [4].

Analytical, diagnostic and therapeutic context of deuteride

The crystal structure of the deuteride was determined by time-of-flight neutron powder diffraction [5].

References

Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions. Pang, J., Pu, J., Gao, J., Truhlar, D.G., Allemann, R.K. J. Am. Chem. Soc. (2006) [Pubmed]
Uridine diphosphate galactose 4-epimerase. pH dependence of the reduction of NAD+ by a substrate analog. Arabshahi, A., Flentke, G.R., Frey, P.A. J. Biol. Chem. (1988) [Pubmed]
Investigation of the mechanism of alkane reductive elimination and skeletal isomerization in Tp'Rh(CNneopentyl)(R)H complexes: the role of alkane complexes. Northcutt, T.O., Wick, D.D., Vetter, A.J., Jones, W.D. J. Am. Chem. Soc. (2001) [Pubmed]
Stereo-specificity for pro-(R) hydrogen of NAD(P)H during enzyme-catalyzed hydride transfer to CL-20. Bhushan, B., Halasz, A., Hawari, J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
New alkaline earth aluminum hydride with one-dimensional zigzag chains of [AlH6]: synthesis and crystal structure of BaAlH5. Zhang, Q.A., Nakamura, Y., Oikawa, K.I., Kamiyama, T., Akiba, E. Inorganic chemistry. (2002) [Pubmed]

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